Name

TOYA, Mika

Official Title

Associate Professor(without tenure)

Affiliation

(Global Center for Science and Engineering)

Sub-affiliation

Sub-affiliation

Research Council (Research Organization)/Affiliated organization(Global Education Center)

Research Grants & Projects

Grant-in-aids for Scientific Research Adoption Situation

Research Classification:

Non-centrosomal microtubules that control the structure and function of kidney tubules

2017/-0-2020/-0

Allocation Class:¥4940000

Research Classification:

Organization and function of non-centrosomal microtubules array in polarized epithelial cells

2013/-0-2016/-0

Allocation Class:¥5330000

Research Classification:

Analysis for the two distinct pathways to form mitotic spindles in C. elegans embryos

Allocation Class:¥4680000

On-campus Research System

Special Research Project

上皮細胞に特徴的な微小管編成が構築されるしくみ

2018

Research Results Outline:上皮細胞は、臓器を構成する主要な成分であり、生体内で頂端―基底の極性をもつ。分化した上皮細胞では、微小管細胞骨格は、頂端―基底の軸に沿って規則正しく配上皮細胞は、臓器を構成する主要な成分であり、生体内で頂端―基底の極性をもつ。分化した上皮細胞では、微小管細胞骨格は、頂端―基底の軸に沿って規則正しく配向する。この特徴的な微小管編成は、上皮細胞が正しく機能するために重要であると考えられているが、編成...上皮細胞は、臓器を構成する主要な成分であり、生体内で頂端―基底の極性をもつ。分化した上皮細胞では、微小管細胞骨格は、頂端―基底の軸に沿って規則正しく配向する。この特徴的な微小管編成は、上皮細胞が正しく機能するために重要であると考えられているが、編成構築のしくみについては、いまだ多くのことが分かっていない。本研究では、幹細胞領域と分化した細胞を同時に観察することが可能な、マウス小腸の上皮組織に着目した。絨毛に隣接して窪んだ、上皮幹細胞を含む領域(陰窩)と、分化した細胞から成る絨毛中央部に存在する細胞について、微小管編成を比較観察し、分化にともなう微小管編成の変化を調べた。

非中心体微小管が関わる腎尿細管構造の生理的役割

2019Collaborator:佐藤政充, 竹市雅俊

Research Results Outline:腎臓は、体内の水分や塩分を調節する重要な役割をもつ。その構造は複雑で、皮質と髄質に分けられる2つの層に、糸球体と尿細管から成るネフロンと呼ばれる最小機腎臓は、体内の水分や塩分を調節する重要な役割をもつ。その構造は複雑で、皮質と髄質に分けられる2つの層に、糸球体と尿細管から成るネフロンと呼ばれる最小機能単位が、多数詰まっている。我々は、中心体に依存しない微小管に結合するCAMSAP3タンパク質の機...腎臓は、体内の水分や塩分を調節する重要な役割をもつ。その構造は複雑で、皮質と髄質に分けられる2つの層に、糸球体と尿細管から成るネフロンと呼ばれる最小機能単位が、多数詰まっている。我々は、中心体に依存しない微小管に結合するCAMSAP3タンパク質の機能欠損マウスにおいて、腎臓の構造異常を見出した。組織化学解析から、Camsap3変異マウスでは、腎皮質に存在する尿細管の一部が拡張することがわかった。本研究課題では、尿および血液サンプルの生化学検査をおこない、CAMSAP3の機能欠損により生じる腎臓の構造異常が、生理的機能に与える影響を調べた。

Lecture Course

Course TitleSchoolYearTerm
Science and Engineering Laboratory 1ASchool of Fundamental Science and Engineering2020spring semester
Science and Engineering Laboratory 1A VSchool of Fundamental Science and Engineering2020spring semester
Science and Engineering Laboratory 1ASchool of Creative Science and Engineering2020spring semester
Science and Engineering Laboratory 1A VSchool of Creative Science and Engineering2020spring semester
Science and Engineering Laboratory 1ASchool of Advanced Science and Engineering2020spring semester
Science and Engineering Laboratory 1A VSchool of Advanced Science and Engineering2020spring semester
Science and Engineering Laboratory 1B IISchool of Fundamental Science and Engineering2020fall semester
Science and Engineering Laboratory 1B IISchool of Creative Science and Engineering2020fall semester
Science and Engineering Laboratory 1B IISchool of Advanced Science and Engineering2020fall semester
Introduction to Bioscience (1)School of Fundamental Science and Engineering2020spring quarter
Introduction to Bioscience (1)School of Fundamental Science and Engineering2020spring quarter
Introduction to Bioscience (1)School of Creative Science and Engineering2020spring quarter
Introduction to Bioscience (1)School of Creative Science and Engineering2020spring quarter
Introduction to Bioscience (1)School of Advanced Science and Engineering2020spring quarter
Introduction to Bioscience (1)School of Advanced Science and Engineering2020spring quarter
Life Science and Medical Bioscience Seminar IISchool of Advanced Science and Engineering2020spring semester
Bioscience Practicals ASchool of Advanced Science and Engineering2020fall semester
Bioscience Practicals BSchool of Advanced Science and Engineering2020spring semester
Graduation Thesis ASchool of Advanced Science and Engineering2020fall semester
Graduation Thesis BSchool of Advanced Science and Engineering2020spring semester
Research Ethics and Intellectual PropertySchool of Advanced Science and Engineering2020fall semester
Seminar on Problem SolvingSchool of Advanced Science and Engineering2020fall semester
Research Design and AnalysisSchool of Advanced Science and Engineering2020fall semester
Laboratory for Advanced Science and Engineering ASchool of Advanced Science and Engineering2020spring quarter
Laboratory for Advanced Science and Engineering ASchool of Advanced Science and Engineering2020spring quarter
Laboratory for Advanced Science and Engineering ASchool of Advanced Science and Engineering2020spring quarter
Laboratory for Advanced Science and Engineering A [S Grade]School of Advanced Science and Engineering2020spring quarter
Laboratory for Advanced Science and Engineering A [S Grade]School of Advanced Science and Engineering2020spring quarter
Laboratory for Advanced Science and Engineering A [S Grade]School of Advanced Science and Engineering2020spring quarter
Laboratory for Advanced Science and Engineering BSchool of Advanced Science and Engineering2020summer quarter
Laboratory for Advanced Science and Engineering BSchool of Advanced Science and Engineering2020summer quarter
Laboratory for Advanced Science and Engineering BSchool of Advanced Science and Engineering2020summer quarter
Laboratory for Advanced Science and Engineering B [S Grade]School of Advanced Science and Engineering2020summer quarter
Laboratory for Advanced Science and Engineering B [S Grade]School of Advanced Science and Engineering2020summer quarter
Laboratory for Advanced Science and Engineering B [S Grade]School of Advanced Science and Engineering2020summer quarter
Current Topics in BiosciencesSchool of Advanced Science and Engineering2020fall semester
Current Topics in Biosciences [S Grade]School of Advanced Science and Engineering2020fall semester
Advanced Bioscience SeminarSchool of Advanced Science and Engineering2020fall semester