Name

IWASAKI, Kiyotaka

Official Title

Professor

Affiliation

(Graduate School of Advanced Science and Engineering)

Contact Information

Mail Address

Mail Address
iwasaki@waseda.jp

Address・Phone Number・Fax Number

Address
TWIns 2-2 #03C204 Wakamatsucho, Shinjuku, Tokyo 162-8480 Japan
Phone Number
+81-353697331
Fax Number
+81-3-52699062

URL

Web Page URL

http://www.waseda.jp/wias/researches/monthly/spot_k_iwasaki.html

http://www.umezu.mech.waseda.ac.jp/about/facu.html

Grant-in-aids for Scientific Researcher Number
20339691

Sub-affiliation

Sub-affiliation

Faculty of Science and Engineering(School of Creative Science and Engineering)

Research Council (Research Organization)/Affiliated organization(Global Education Center)

Affiliated Institutes

医療レギュラトリ―サイエンス研究所

研究所員 2013-2015

医療レギュラトリ―サイエンス研究所

研究所員 2015-

理工学術院総合研究所(理工学研究所)

兼任研究員 2018-

Educational background・Degree

Educational background

-1997 Waseda University Faculty of Science and Engineering
-1999 Waseda University Graduate School, Division of Science and Engineering Mechanical Engineering
-2002 Waseda University Graduate School, Division of Science and Engineering Mechanical Engineering

Degree

Doctor of Engineering Coursework Waseda University Biomedical engineering/Biomaterial science and engineering

Career

2001/04-2004/03Research Associate, Department of Mechanical Engineering, Waseda University
2001-2004Research Associate, Major in Integrative Bioscience and Biomedical Engineering, Graduate School of Science and Engineering, Waseda University
2004/04-2004/06Lecturer, Graduate School of Science and Engineering, Waseda University
2004/07-2006/06Lecturer, Institute for Biomedical Engineering, ASMeW, Waseda University
2006/04-2007/02Associate Professor,
2004/10-2007/02Research Scientist, Laboratory for Tissue Engineering and Regenerative Medicine (Director: Dr. Charles Vacanti), Brigham and Women’s Hospital, Harvard Medical School
2007/03-2012/03Present Associate Professor, Waseda Institute for Advanced Study, Waseda University
2013/04-2014/03Waseda Research Institute for Science and Engineering, Waseda University
2014/04-Professor, Waseda Research Institute for Science and Engineering, Waseda University

Academic Society Joined

International Faculty

Research Field

Keywords

Cardiovascular Biomedical Engineering, Tissue Engineering, Regulatory Science, Non-clinical testing methodology for Medical Device

Grants-in-Aid for Scientific Research classification

Complex systems / Biomedical engineering / Biomedical engineering/Biomaterial science and engineering

Technology Seeds

A durability testing device for stents and a method of evaluation

Seeds Field:Life sciences, Manufacturing Technology

Acellularization of heart valves

Seeds Field:Life sciences, Manufacturing Technology

Research interests Career

Establishment of reliable methodology for accelerated fatigue tests of polymer heart valves.

Current Research Theme Keywords:Accelerated fatigue test,polymer valve,ISO standard

Individual research allowance

Development of a durable polymer valve

Current Research Theme Keywords:Polymer valve,calcification,accelerated fatigue test

Cooperative Research within Japan

Development of an in-vitro closed circuit for blood compatibility test of biomaterials in pulsatile conditions

Current Research Theme Keywords:Anti-thrombogenicity,In-vitro circuit,blood compatibility

Individual research allowance

Paper

医療機器・材料の血液適合性評価と,生体外(in vitro)で可能な評価手法の展望,生体適合性制御と要求特性掌握から実践する高分子バイオマテリアルの設計・開発戦略

岩崎清隆

サイエンス&テクノロジー p.247 - 2582014/05-

DuraHeart左心補助人工心臓システムの市販後における改良に関する報告

中谷武嗣,許俊鋭,澤芳樹,戸田宏一,岩﨑清隆,梅津光生,山根隆志,荒井裕国,磯部光章,小野稔,山崎健二

人工臓器 42(3) p.262 - 2742013-

Development of a miniature undulation pump for the distributed artificial heart

Y.Abe, T.Ono, T.Isoyama, S.Mochizuki, K.Iwasaki, T.Chinzei, I.Saito, A.Kouno, K.Imachi

Artif Organs 24(8) p.656 - 6582000-

耐久性向上を目指した高分子製人工心臓弁の開発とその総合的評価

岩﨑清隆

ライフサポート 11(2) p.12 - 141999-

人工弁の最近の進歩

尾崎重之,菊地眞,岩﨑清隆,守本裕司

バイオマテリアル 22(2) p.89 - 982004-

人工弁,人工臓器—最近の進歩

岩﨑清隆,梅津光生

人工臓器 33(3) p.178 - 1862004-

ステントの 至適拡張方法の検討:From bench to bedside

上野高史,光武良亮,横山晋二,板家直樹,川崎友裕,挽地裕,岩﨑清隆

人工臓器 39(3) p.222 - 2262010-

血管拡張ステントの加速耐久 試験に関する研究

岩﨑清隆,野口祐介,岸上翔,八木下雄一,梅津光生

豊田研究報告 64p.117 - 1202011-

ヒト頚動脈病変の形状及び硬さを模擬した2層シリコーン狭窄血管モデルを用いたステントに必 要な拡張力に関する検討

岡本吉弘,田中智美,小橋宏行,犬飼孟,山家弘雄,岩﨑清隆,梅津光生

医工学治療 23(3) p.197 - 2052011-

埋込み型補助人工心臓システムEVAHEARTの耐久性評価

北野智哉,宮越貴之,小林信治,得能敏正,山崎健二,岩﨑清隆,梅津光生

生体医工学 49(6) p.918 - 9242011-

新しい僧帽弁ステントレス生体弁Normoの開発

加瀬川均,岩﨑清隆,梅津光生

人工臓器 41(3) p.176 - 1792012-

Post-market Risk Assessment based on Malfunction Reports of Implantable Arrhythmia devices in Japan, Pharmaceutical and Medical Device Regulatory Science(医薬品医療機器レギュラトリーサイエンス)

N.Okura, K.Iwasaki, H.Kasanuki

44(4) p.352 - 3562013-

冠動脈ステントの疲労破壊:破損耐久性の可視化

岩﨑清隆,梅津光生

可視化情報学会誌 33(131) p.139 - 1442013/10-

組織無細胞化技術による再生医療

岩﨑清隆

日本機械学会誌 117(1142) p.28 - 312014/01-

冠動脈ステントの3回拡張法と臨床実践での評価

山本匡,岩﨑清隆,新井淳,北原茂美,梅津光生

生体医工学 51(6) p.350 - 3562014-

Application of the International Medical Alarm Standard in Clinical Practice.Pharmaceutical and Medical Device Regulatory Science(医薬品医療機器レギュラトリーサイエンス)

Masahiro Echigo, Hiroshi Kasanuki, Kiyotaka Iwasaki, Mitsuo Umezu

45(3) 2014-

Awareness of Electromagnetic Interference in Patients with Cardiac Implantable Electronic Devices: An Analysis of Hospital Explanations and Other Factors. Regulatory Science of Mecical Products(医薬品医療機器レギュラトリーサイエンス)

F.Aoki, K.Iwasaki, M.Umezu, H.Kasanuki

4(2) 2014-

Three-dimensional fluid mechanics of the sinus of Valsalva with a bileaflet mechanical heart valve

T.Yagi, W.Yang, K.Iwasaki, M.Umezu

Proceedings of ASME 2007 Summer Bioengineering Conference 2007-

Calibration System for Pulse Spectrophotometry Using a Double-Layer Pulsation Flow-Cell

M.Oura, N. Kobayashi, S.Yamamori, S.Takeda, K.Iwasaki, M.Umezu

IEEE EMBS p.896 - 8992009-

Investigation of Mechanical Load onProximal Left Anterior Descending of Coroary Artery

T.Yamamoto, K.Iwasaki, J.Arai, K.Ohori, M.Umezu

IFMBE Proceedings 43p.805 - 8082014-

Effect of the elastic conditions around a stentless valvular bioprosthesis on opening behavior

T.Fujimoto, D.Kawaguchi, Y.Shiraishi, K.Iwasaki, M.Arita, T.Tanaka, M.Umezu

J Artif Organs 7(3) p.133 - 1362004-

Comparing accuracy of cerebral aneurysm size measurements from three routine investigations: computed tomography, magnetic resonance imaging, and digital subtraction angiography

H.Takao, Y.Murayama, T.Ishibashi, T.Saguchi, M.Ebara, H.Arakawa, K.Irie, K.Iwasaki, M.Umezu, T.Abe

Neurol Med Chir (Tokyo) 50(10) p.893 - 899

Assessment of a novel stentless mitral valve using a pulsatile mitral valve simulator

H.Kasegawa, K.Iwasaki, S.Kusunose, R.Tatsuta, T.Doi, H.Yasuda, M.Umezu

The J Heart Valve Dis 21(1) p.71 - 752011-

Tissue engineered trachea using decellularized aorta

AC Paz, K.Kojima, K.Iwasaki, JD Ross, M.Umezu

J Bioengineer & Biomedical Sci. 2011-

Tensile strength of human pericardium treated with glutaraldehyde

H.Yamashita, S.Ozaki, K.Iwasaki, I.Kawase, Y.Nozawa, M.Umezu

Ann Thorac Cardiovasc Surg 18(5) p.434 - 4372012-

Preliminary study on the development of a system dynamics model: the case of EVAHEART

Kato T, Umezu M, Iwasaki K, Kasanuki H, Takahashi Y

J Artif Organs 16(2) p.242 - 2472013-

Numerical analysis of blood flow distribution in 4- and 3-branch vascular grafts

Konoura C, Yagi T, Nakamura M, Iwasaki K, Qian Y, Okuda S, Yoshitake A, Shimizu H, Yozu R, Umezu M

J Artif Organs 16(2) p.157 - 1632013-

Optimal kissing balloon inflation after single-stent deployment in a coronary bifurcation model

Y.Murasato, K.Iwasaki, T.Yamamoto, T.Yagi, Y.Hikichi, Y.Suematsu, T.Yamamoto

EuroIntervention 2014-

DOI

Simultaneous comparison of thrombogenic reactions to different combinations of anticoagulants, activated clotting times, and materials

M.Nagai, K.Iwasaki, M.Umezu, M.Ozaki

J Biomed Mater Res B Appl Biomater. 2014/03-

DOI

Recent perspective on coronary bifurcation intervention: statement of the “Bifurcation Club in KOKURA”

Murasato Y, Hikichi Y, Nakamura S, Kajiya F, Iwasaki K, Kinoshita Y, Yamawaki M, Shinke T, Yamashita T, Choo GH, Nam CW, Kim YH, Jepson N, Ferenc M

4p.295 - 304

医工融合に基づく先進医療研究の展開

岩﨑清隆,梅津光生

可視化情報 30(1) p.3 - 6

Experimental investigation to ensure a safety of the exchange of extracorporeal-type ventricular assist devices in long-term-use patients

Tanaka T, Kume R, Kusunose S, Tatsuta R, Igarashi T, Ito K, Iwasaki K, Umezu M

IFMBE Proceedings 31p.378 - 381

Silicone vascular models for analysis of carotid artery stenting

Okamoto Y, Inukai H, Kobashi H, Yamaga H, Yagi T, Iwasaki K, Shiurba R, Umezu M

IFMBE Proceedings 31p.398 - 401

臨床用補助人工心臓交換時の安全性に関する実験的研究

田中隆,古里正光,石澤祐馬,伊藤一彦,岩崎清隆,銭逸,梅津光生

体外循環技術 36(2) p.108 - 1142009/06-

3次元心筋組織構築のためのバイオリアクターの開発

坂口勝久,沢田里智,清水達也,岩崎清隆,大和雅之,梅津光生,岡野光夫

ライフサポート p.104 - 1092009-

Calibration System for Pulse Spectrophotometry Using a Double-Layer Pulsation Flow-Cell

Oura M, Kobayashi N, Yamamori S, Takeda S, Iwasaki K, Umezu M

IEEE EMBS p.896 - 8992009-

Vacanti CA: Bioengineered three-layered robust and elastic artery using hemodynamically-equivalent pulsatile bioreactor

Iwasaki K, Kojima K, Kodama S, Paz CA, Chambers M, Umezu M

Circulation 118p.52 - 572008-

Development of a compact mock circulatory system and a new flow-cell model for pulse spectrophotometry

Oura M, Kobayashi N, Takeda S, Iwasaki K, Umezu M

IEEE Engineering in Medicine and Biology Society p.670 - 6732008-

Successful reproduction on in-vivo fracture of an endovascular stent in superficial femoral artery utilizing a novel multi-loading durability test system, Proceedings of the 13th International Conference on Biomedical Engineering

Iwasaki K, Tsubouchi S, Hama Y, Umezu M

Proceedings of the 12th International Conference on Biomedical Engineering p.1443 - 14462008/12-

Development of evaluation test method for the possibility of central venous catheter perforation caused by the insertion angle of a guidewire and a dilator

Uematsu M, Arita M, Iwasaki K, Tanaka T, Ohta T, Umezu M, Tsuchiya T

Proceedings of the 13th International Conference on Biomedical Engineering p.1183 - 11862008/12-

In-vitro evaluation method to measure radial force of various stents

Okamoto Y, Tanaka T, Kobashi H, Iwasaki K, Umezu M

Proceedings of the 13th International Conference on Biomedical Engineering p.1053 - 10562008/12-

New challenge for studying flow-induced blood damage

Yagi T, Wakasa S, Tokunaga N, Akimoto Y, Akutsu T, Iwasaki K, Umezu M

Proceedings of the 13th International Conference on Biomedical Engineering p.1430 - 14332008/12-

Microscale visualization of erythrocyte deformation by colliding with a rigid surface using a high-speed impinging jet

Wakasa S, Yagi T, Akimoto Y, Tokunaga N, Iwasaki K, Umezu M

Proceedings of the 13th International Conference on Biomedical Engineering p.1422 - 14252008/12-

Biomedical engineering analysis of the rupture risk of cerebral aneurysms: Flow comparison of three small pre-ruptured versus six large unruptured cases

Kamoda A, Yagi T, Sato A, Qian Y, Iwasaki K, Umezu M

Proceedings of the 13th International Conference on Biomedical Engineering p.1600 - 16032008/12-

Fabrication of three-dimensional tissues with perfused microchannels

Sakaguchi K, Shimizu T, Iwasaki K, Yamato M, Umezu M, Okano T

Proceedings of the 13th International Conference on Biomedical Engineering p.1213 - 12162008/12-

本邦初の次世代型補助人工心臓EVAHEART-自宅療養・就労復帰が可能となった

山嵜健二,梅津光生,太田英輔,富岡淳,岩清隆,石原一彦

油空圧技術 p.12 - 162008-

Japanese-made implantable centrifugal type ventricular assist system(LVAS):EVAHEART

Umezu M, Yamazaki K, Yamazaki S, Iwasaki K, Miyakoshi T, Kitano T, Tokono T

Biocybernetics and Biomedical Engineering, Polish Academy of Sciences Institute of Biocybernetics and Biomedical Engineering 27(1月2日) p.111 - 1192007/06-

Characteristics of spiral vortex pump driven by two different drivers

Ito K, Sudo T, Shima T, Kouno Y, Ohnishi Y, Tanaka T, Iwasaki K, Fujimoto T, Umezu M

Biocybernetics and Biomedical Engineering 27(1月2日) p.121 - 1322007/06-

Tensile test to ensure a safety of cannula connection in clinical ventricular assist device(VAD)

Tanaka T, Shima T, Furusato M, Kokuzawa Y, Ito K, Iwasaki K, Qian Y, Umezu M

Life system modeling and simulation 2007 proccedings p.546 - 5522007/09-

A reproduction of inflow restriction in the mock circulatory system to evaluate a hydrodynamic performance of a ventricular assist device in practical conditions

Furusato M, Shima T, Kokuzawa Y, Ito K, Tanaka T, Iwasaki K, Qian Y, Umezu M, Yan Z, Ling Z

Life system modeling and simulation 2007 proccedings p.553 - 5582007/09-

Investigation of a hyderodynamic performance of a ventricular assist device after its long-term use in clinical application

Kokuzawa Y, Shima T, Furusato M, Ito K, Tanaka T, Igarashi T Nishinaka T, Iwasaki K, Umezu M

Life system modeling and simulation 2007 proccedings p.429 - 4352007/09-

量産向け旋回渦流型人工心臓内面検査装置の開発

田中隆,古里正光,石澤祐馬,伊藤一彦,岩清隆,梅津光生

第5回生活支援工学系学会連合大会講演予稿集 p.242007/10-

冠動脈バイパス手術における血管吻合手技の定量かに向けた基礎検討

第16回日本コンピュータ外科学会大会・第17回コンピュータ支援画像診断学会大会,合同論文集

p.83 - 842007/11-

組織工学と再生医療

岩清隆

人工臓器36(3) p.213 - 2142007-

In vivo複合負荷環境を模擬した加速試験装置による末梢ステントの耐久試験

岩清隆,錦織晃,坪内俊介,梅津光生

日本機械学会創立110周年記念2007年度年次大会講演論文集 5p.301 - 3022007/09-

走査型ステレオPIV法を用いた異なる大動脈バルサルバ洞形状をもつ Valved Graft 内の3次元流動特性

八木高伸,若狭翔太郎,William Yang, 岩清隆,梅津光生

日本機械学会創立110周年記念2007年度年次大会講演論文集 5p.295 - 2962007/09-

リアルタイム周波数解析を用いた人工弁閉鎖時に発達する瞬時高周波ストレスの検討

石川大輔,八木高伸,須藤宏幸,若狭翔太朗,阿久津敏乃介,岩清隆,梅津光生

第19回バイオエンジニアリング講演会 講演論文集 p.60 - 612007/01-

ステレオPIV法を用いた大動脈バルサルバ洞内の3次元流れ場構造に関する基礎知識

須藤宏幸,八木高伸,石川大輔,若狭翔太朗,William Yang,岩清隆,梅津光生

第19回バイオエンジニアリング講演会 講演論文集 p.62 - 632007/01-

末梢Stent耐久性能評価を目的としたねじり型加速疲労試験装置の開発

第19回バイオエンジニアリング講演会 講演論文集 p.80 - 812007/01-

脳血管系疾患のCFDによる解析:PIV可視化実験とのValidation

原田哲司,福井弘一,銭逸,岩清隆,梅津光生,高尾洋之,石橋敏寛,村山雄一

第19回バイオエンジニアリング講演会 講演論文集 p.88 - 892007/01-

Coil compaction予測のための時系列PIV法を用いた実形状弾性脳動脈瘤モデル内の流れの可視化

松本徹,岩清隆,八木高伸,福島桃子,鴨田明憲,梅津光生,阿久津敏乃介,高尾洋之,石橋敏寛,村山雄一

第19回バイオエンジニアリング講演会 講演論文集 p.82 - 832007/01-

再生医療を支える最先端技術と将来への展望

梅津光生,岩清隆

第5回薬事エキスパート研修会 要旨集 p.8 - 112007/02-

Multiplane scanning Stereo-PIV measurements of flow inside a spiral vortex pulsatile blood pump

Yagi.T, Yang W, Ishikawa D, Sudo H, Iwasaki K, Umezu M

Proceedings of the 13th International Symposium on Applications of Laser Techniques to Fluid Mechanics (2006) 2006-

Development of “Patient Robot”; Measurement system of myocardial behaviors for the quantitative evaluation of the surgical robot technology

Uematsu M, Ando H, Morita A, Uesugi S, Iwasaki K, Umezu M

The first IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics 2006-

Real-time planar spectral analysis of instantaneous high-frequency stress on blood cells downstream of an artificial heart valve

Yagi T, Ishikawa D, Sudo H, Yang W, Iwasaki K, Umezu M

Proceedings of the 12th International Symposium on Flow Visualization 2006-

3D quantitative flow visualization of a spiral vortex pulsatile blood pump using stereoscopic PIV

Yang W, Yagi T, Ishikawa D, Sudo H, Iwasaki K, Umezu M, Tu JY

Proceedings of the 12th International Symposium on Flow Visualization 2006-

Stereoscopic particle image velocimetry for application in three-dimensional flow within a spiral vortex pulsatile blood pump

Yagi T, Yang W, Ishikawa D, Iwasaki K, Umezu M

Biocybernetics and Biomedical Engineering 26(2) p.39 - 482006-

Biomedical engineering analysis on the effectiveness of cardiovascular surgery: Anastomosis methods for coronary artery bypass grafting "jointly worked"

Umezu M, Kawai J, Suehiro J, Arita M, Shiraishi Y, Iwasaki K, Tanak T, Akutsu T, Niinami H

Lecture Notes of the ICB Seminar 7th Polish-Japanese Seminar on New Technologies For Future Artificial Organs p.80 - 862005/08-

Stereoscopic particle image velocimetry measurements toward three dimensional flow investigations within the spiral vortex blood pump "jointly worked"

Yagi T, Yang W, Ishikawa D, Iwasaki K, Umezu M

Lecture Notes of the ICB Seminar 8th Polish-Japanese Seminar on New Technologies For Future Artificial Organs p.106 - 1122005/08-

Biomedical engineering analysis of effectiveness of cardiovascular surgery: Anastomosis methods for coronary artery bypass grafting

Umezu M, Kawai J, Suehiro J, Arita M, Shiraishi Y, Iwasaki K, Tanaka T, Akutsu T, Niinami H

Biocybernetics and biomedical engineering 2006 26(1) p.61 - 672006/02-

左心室形成術における切除線決定のための診断法に関する基礎的検討

植松美幸,白石泰之,関根一光,山家智之,西條芳文,安藤隼人,朴栄光,武田朴,岩清隆,梅津光生

生体医工学 43(4) p.653 - 6602005/12-

Innovative bioreactor technologies produced a completely decellularized and pre-endothelialized functional aortic valve

Iwasaki K, Ozaki S, Kawai T, Yamaguchi S, Eto M, Ohba Y, Umezu M

Proceedings of 12th International Conference on Biomedical Engineering 12p.1A2 - 072005-

Development of an inexpensive first-aid type ventricular assist device driven by IABP consoles

Sudo T, Iwasaki K, Ohnishi Y, Shima T, Tanaka T, Ito K, Umezu M

Proceedings of 12th International Conference on Biomedical Engineering 12p.1A3 - 052005-

An experimental investigation of three-dimensional flow structures within the spiral vortex ventricular assist device using stereoscopic PIV

Yagi T, Yang W, Ishikawa D, Sudo H, Iwasaki K, Umezu M

Proceedings of 12th International Conference on Biomedical Engineering 12p.1A3 - 062005-

An investigation of instantaneous high-frequency turbulent stress in the vicinity of artificial heart valves using wavelet transform analysis of dynamic PIV measurements

Yagi T, Ishikawa D, Sudo H, Akutsu T, Yang W, Iwasaki K, Umezu M

Proceedings of 12th International Conference on Biomedical Engineering 12p.1B2 - 062005-

Influence of drive conditions on hemodynamic performance of undulation type artificial heart

Sone D, Yada Y, Iwasaki K, Saito I, Umezu M, Abe Y, Imachi K

Proceedings of 12th International Conference on Biomedical Engineering 12p.1A3 - 042005-

Regional myocardial behaviour cardiac surface under arrhythmic conditions

Uematsu M, Shiraishi Y, Sekine K, Yambe T, Saijo Y, Ando H, Park Y, Takeda S, Iwasaki K, Umezu M

Proceedings of 12th International Conference on Biomedical Engineering 12p.1A5 - 05

CMC内蔵型シリコン管の製作と性能

朴栄光,梅津光生,松本徹,岩清隆,田中隆,O Medvedev,青見茂之,元島栖二

第15回カーボンマイクロコイル(CMC)研究会 p.37 - 402004/06-

CMCの医療機器応用への期待

梅津光生,朴栄光,松本徹,岩清隆,田中隆,O Medvedev,藤江正克,高西淳夫,山川宏,元島栖二

第15回カーボンマイクロコイル(CMC)研究会 p.19 - 222004/06-

In vitro evaluating system for prosthetic heart valves

Fujimoto T, Tsutsumi Y, Kawaguchi D, Shiraishi Y, Iwasaki K, Arita M, Umezu M

芝浦工業大学学術フロンティア推進事業2002年度研究成果報告 p.17 - 262003/12-

Biomedical engineering approach to evaluate anastomosis methods for coronary artery bypass grafting

Umezu M, Kawai J, Suehiro J, Arita M, Shiraishi Y, Iwasaki K, Tanaka T, Niinami H

Journal of Shanghai University 2004 10p.25 - 282004/10-

In vitro mitral simulator to evaluate effectiveness of valvoplasty technique

Doi H, Arita M, Okuda M, Noda R, Iwasaki K, Tanaka T, Kasegawa H, Umezu M

Journal of Shanghai University 2004 10p.29 - 312004/10-

In vitro hydrodynamic test and in vitro hemolysis test for development of inexpensive spiral vortex ventricular assisting system using IABP console

OHNISHI Y, IWASAKI K, MIZUTA H, SUDO T, MUTO S, SHIMA T, TANAKA T, ITO K, UMEZU M

Journal of Shanghai University 2004 10p.32 - 362004/10-

Present status of Japanese implantable centrifugsl type ventricular assit system(LVAS):Evaheart

Umezu M, Yamazaki K, Yamazaki S, Kurasawa H, Iwasaki K

First Shanghai congress on heart assist and mechanical circulatory support p.27 - 292004/12-

Effect of the elastic conditions around a stentless valvular bioprosthesis on opening behavior

Fujimoto T, Kasegawa D, Shiraishi Y, Iwasaki K, Arita M, Tamaka T, Umezu M

The Japanese Society for Artificial organs 2004 7p.133 - 1362004-

脳動脈瘤治療法の評価を目的とした拍動循環シミュレータの開発

栗山仁志,岩崎清隆,八木高伸,高島俊洋,藤井麻由,石川大輔,梅津光生,阿久津敏乃介,高尾洋之,石橋敏寛,村山雄一

第17回バイオエンジニアリング講演会 講演論文集 p.397 - 3982005/01-

様々な負荷に対する心機能変化計測への試み

植松美幸,白石泰之,関根一光,山家智之,西條芳文,武藤俊介,朴栄光,安藤隼人,松本徹,武田朴,岩崎清隆,梅津光生,内山明彦

電気学会研究会資料 p.23 - 262005/02-

人工弁

岩崎清隆,梅津光生

人工臓器 33(3) p.178 - 1862004/12-

低価格旋廻渦流型拍動血液ポンプの製作法の検討

須藤知浩,岩清隆,吉田敬,田中隆,伊藤一彦,梅津光生

第2回生活支援工学系学会連合大会講演予稿集 p.155 - 1562004/09-

拍動型人工心臓材料のin vitro血液適応性評価方法の検討

竹内有理,岩清隆,佐伯航,石原一彦,梅津光生

第2回生活支援工学系学会連合大会講演予稿集 p.157 - 1582004/09-

旋廻渦流型人工心臓量産化のための金型形状の検討

田中隆,岩清隆,伊藤一彦,梅津光生

第2回生活支援工学系学会連合大会講演予稿集 p.203 - 2042004/09-

人工弁の最新の進歩

尾崎重之, 菊地眞, 岩崎清隆, 守本裕司

バイオマテリアル 22(2) p.89 - 982004-

Development of a polymer bileaflet vale to realize a low-cost pulatile blood pump

Iwasaki K, Umezu M, Iijima K, Inoue A, Imachi K, Ye CX

Artificial Organs 27(1) p.78 - 832003-

Third model of the undulation pump total artificial heart

Abe Y, Chinzei T, Isoyama T, Ono T, Mochizuki S, Saito I, Iwasaki K, Ishimaru M, Baba A, Kouno A, Ozeki T, Tohyama T, Imachi K

ASAIO J 49(1) p.123 - 1272003-

A novel in vitro device to investigate a calcification mechanism on cardiovascular implants

Iwasaki K, Umezu M, Imachi K

6th Polish-Japanese symposium on bio-medical engineering p.41 - 422003-

Advance in animal experiments with the undulation pump total artificial heart: 50 and 54 day survival periods with 1/R control

Abe Y, Chinzei T, Isoyama T, Kobayashi S, Ono T, Saito I, Iwasaki K, Ishimaru M, Baba A, Kouno A, Ozeki T, Tohyama T, Imachi K

ASAIO J 49(3) p.325 - 3322003-

Progress in the control system of the undulation pump total artificial heart

Chinzei T, Abe Y, Ishimaru M, Isoyama T, Ono T, Mochizuki S, Saito I, Iwasaki K, Baba A, Kouno A, Ozeki T, Takiura K, Tohyama T, Nakagawa H, Imachi K

Artificial Organs 27(1) p.27 - 332003-

大動脈弁置換用を目指したブタ組織弁の脱細胞化手法の検討及びin vitro拍動下での細胞播種用バイオリアクターの開発

岩崎清隆,尾崎重之,中澤剛,今井裕一,守本裕司,石原雅之,菊地眞,梅津光生

日本機械学会関東支部第9期総会講演会講演論文集 p.83 - 842003-

心臓病の治療効果評価のための左心系モデルの開発

野口康雄,梅津光生,岩崎清隆

日本機械学会第16回バイオエンジニアリング講演会講演論文集 p.63 - 642004/01-

脱細胞化異種大動脈弁の開発:拍動循環下でのマイクロ波均一照射による完全脱細胞化および拍動循環での組織再内皮細胞化手法の検討

岩崎清隆, 尾崎重之, 中澤剛, 今井裕一, 川井貴裕, 石原雅之, 守本裕司, 菊地眞,梅津光生

日本機械学会第16回バイオエンジニアリング講演会講演論文集 p.437 - 4382004/01-

新規の完全大気非接触型拍動動流循環回路による人工臓器のin vitro抗血栓性評価方法の確立に向けての挑戦

岩崎清隆, 佐伯航, 竹内有理, 梅津光生, 石原一彦, 井街宏, 桜井靖久

日本機械学会第16回バイオエンジニアリング講演会講演論文集 p.217 - 2182004/01-

医用高分子材料の長期血液循環使用下で問題となるカルシウム沈着特性のin vitro 評価試験手法の新開発

岩崎清隆,梅津光生,井上旭,井街宏

日本機械学会第16回バイオエンジニアリング講演会講演論文集 p.219 - 2202004/01-

Implications for the establishment of accelerated fatigue test protocols for prosthetic heart valves

Iwasaki K, Umezu M, Iijima K, Imachi K

Artificial Organs 26(5) p.420 - 4292002/05-

Left Ventricle simulator for surgeons’support

Umezu M, Arita M, Iwasaki K, Shiraishi Y, Tono S, Uchida K

Biocybernetics and Biomedical Engineering 2002 22(4) p.47 - 532002/09-

In vitro evaluating system for prosthetic heart valves in a case of the Jyros Valve

Fujimoto T, Tsutsumi Y, Shiraishi Y, Iwasaki K, Yoshida M, Umezu M, J.Begg, J.Woodward

Biocybernetics and Biomedical Engineering 2002 22(4) p.46 - 462002/09-

The improved jellyfish valve:Durability enhancement with sufficient blood compatibility

Iwasaki K, Umezu M, Abe Y, Chinzei T, Isoyama T, Saito I, Ishimaru M, Imachi K

ASAIO Journal 2002 48p.532 - 5372002/09-

A challenge to develop an inexpensive “Spiral Vortex Pump”

Tsujimoto T, Iwasaki K, Saeki W, Yoshida K, Arita M, Umezu M, Quian Y, Chun-Xiu Ye, Imachi K, Ishiwata K, Tanaka T

Proceeding of Asian Simulation Conference/ The 5th International Conference System simulation and scientific computing p.1040 - 10442002/11-

Spiral Vortex ventricular assist device : Improvement by engineering analysis and simulation

Iwasaki K, Umezu M, Ye CX, Nugent A, Nakamura T, Arita M, Yi Q, Tanaka T, Imachi K, Ishihara K, Chang V

Proc. Of the Asian Simulation Conference / the 5th International Conference on system Simulation and Scientific Computing p.1035 - 10392002-

An inexpensive pulsatile blood pump: Fabrication strategies and in vitro reliable methodology to evaluate blood compatibility

Iwasaki K, Umezu M, Tsujimoto T, Yoshida K, Saeki W, Yi Q, Ishihara K, Imachi K, Sakurai Y

Proc. of the 11th International Conference on Biomedical Engineering 2002-

Biomedical Engineering approaches to evaluate a function of artificial organs

Umezu M,Shiraishi Y, Iwasaki K, Arita M, Shimizu T, Okano T, Sakurai Y

Proc. of the 11th International Conference on Biomedical Engineering 2002-

人工臓器のin vitro抗血栓性評価を目的とした完全大気非接触型拍動流試験回路の開発

岩崎清隆,梅津光生,佐伯航,石原一彦,井街宏

第15回バイオエンジニアリング講演会講演論文集 p.361 - 3622003-

Ripple reduction control of the undulation pump total artificial heart

Saito I, Chinzei T, Mochizuki S, Abe Y, Isoyama T, Iwasaki K, Suzuki T, Karita T, Ono T, kouno A, Ishimaru M Baba A, Ozeki T, Tohyama T, Kobayashi S, Imachi K

Artificial Organs 26(1) 2002-

ブタ僧帽弁を組み込んだ手術支援シミュレータの開発—機械式循環モデルの有効活用例—

岩崎清隆,内田浩司,有田誠,加瀬川均,梅津光生

BME 16(8) p.20 - 272002-

Method of ranking of heart valve characteristics at mitral position based on statistical Model analysis

Arita M, Iwasaki K, Umezu M, Yoshida M, Fujimoto T, Suma H, Isomura T

The Japanese Society for Artificial Organs 4p.131 - 1372001/04-

Extension of durability of jellyfish valve for lpng-term use in artificial hearts

Iwasaki K, Unezu M, Imachi K, Abe Y, Chinzei T, Isoyama T, Saito I, Fujimoto T

Journal of Congestive Heart and Circulatory Supphort(2001) 1(4) p.293 - 2972001/06-

In vitro performance of “EVAHEART”

Shiraishi Y, Saito Y, Moriyama H, Iwasaki K, Umezu M, Fujimoto T, Miyakoshi T, Kitano T, Tokuno T, Yamazaki K

Proceedings 3rd Japan-Australia Cardiovascular Bioengineering Symposium p.25 - 262001/11-

Improvement of a polymer bileaflet valve to realize a low-price pulsatile blood pump

Proceedings 3rd Japan-Australia Cardiovascular Bioengineering Symposium p.29 - 302001/11-

Design improvement of the jellyfish valve for long-term use in a artificial hearts

Iwasaki K, Umezu M, Imachi K, Iijima K, Fujimoto T

The International Journal of Artificial Organs 24(7) p.463 - 4692001-

Spiral vortex ventricular assist device : Its history and present status

Umezu M, Ye CX, Nugent A, Nakamura T, Iwasaki K, Arita M, Shiraishi Y, Tanaka T, Imachi K, Ishihara K, Chang V.P

Proceedings 2nd Wasda-Renji Hospital BioMedical Engineering Symposium p.6 - 72002/03-

A challenge to develop an Inexpensive spiral vortex pump

Iwasaki K, Umezu M, Tsujimoto T, Saeki W, Inoue A, Nakazawa T, Arita M, Ye CX, Imachi K, Ishiwata K, Tanaka T

Proceedings 2nd Wasda-Renji Hospital BioMedical Engineering Symposium p.8 - 102001/03-

ブタ僧帽弁を組み込んだ手術支援シミュレータ

岩清隆,内田浩司,有田誠,加瀬川均,梅津光生

第15回日本ME学会秋季大会論文集 p.61 - 622001/11-

A new hypothesis on the mechanism of calcification formed on a blood contacted polymer surface

Imachi K, Chinzei T, Abe Y, Mabuchi K, Matsuura H, Karita T, Iwasaki K, Mochizuki S, Son YP, Saito I, Kouno A

J Artif Organs 4(1) p.74 - 822001-

One month survival with the undulation pump total artificial heart in a goat

Abe Y, Chinzei T, Isoyama T, Ono T, Mochizuki S, Saito I, Iwasaki K, Ishimaru M, Karita T, Kouno A, Baba K, Imachi K

Artificial Organs 25(1) p.69 - 712001-

Progress in the development of the undulation pump total artificial heart

Abe Y, Chinzei T, Isoyama T, Ono T, Mochizuki S, Saito I, Iwasaki K, Ishimaru M, Baba A, Kouno A, Karita T, Baba K, Imachi K

Journal of Congestive Heart Failure and Circulatory Support 1(4) p.167 - 1702001-

Design of atrial cuff for the undulation pump total artificial heart

Imachi K, Chinzei T, Abe Y, Isoyama T, Ono T, Mochizuki S, Saito I, Ishimaru M, Iwasaki K, Mama A, Karita T, Ozeki T, Kouno A

Journal of Congestive Heart Failure and Circulatory Support 1(4) p.195 - 2002001-

Extension of durability of jellyfish valve for long-term use in artificial hearts

Iwasaki K, Umezu M, Imachi K, Abe Y, Chinzei T, Isoyama T, Saito I, Fujimoto T

Journal of Congestive Heart Failure and Circulatory Support 1(4) p.293 - 2972001-

Miniature undulation pump for the study of renal circulation

Saito I, Abe Y, Chinzei T, Ono T, Isoyama T, Mochizuki S, Iwasaki K, Kouno A, Karita T, Ishimaru M, Baba A, Imachi K

Journal of Congestive Heart Failure and Circulatory Support 1(4) p.321 - 3252001-

Flow-transformed pulsatile total artificial heart using axial flow blood pump

Isoyama T, Chinzei T, Abe Y, Ono T, Mochizuki S, Saito I, Ishimaru M, Iwasaki K, Baba A, Karita T, Ozeki T, Kouno A, Imachi K

Journal of Congestive Heart Failure and Circulatory Support 1(4) p.327 - 3302001-

A new hypothesis on the mechanism of calcification formed ona blood-contacted polymer surface

井街宏,鎮西恒雄,阿部浩輔,満渕邦彦,松浦弘幸,苅田達郎,岩清隆,望月修一,孫艶萍,斎藤逸郎,河野明正,小野俊哉

Journal of Artificial Organs 4p.74 - 82

Accelerated fatigue testing method for heart valves

Umezu M, Iwasaki K, Imachi h

10th International Conference On Biomedical Engineering p.51 - 512000/12-

In vitro performance tests of a newly-developed bileaflet polymer valve

Iwasaki K, Umezu M, Imachi H, Iijima K, Morita M, Ye CX

10th International Conference On Biomedical Engineering p.343 - 3432000/12-

冠動脈ステントの力学的挙動試験

梅津光生,堀切芳一,岩清隆,藤本哲男

人工臓器 29(1) p.99 - 992000/02-

高速ビデオカメラを用いた人工弁の回転に関する検討

藤本哲男,比留間信義,堤祐一,岩清隆,白石泰之,梅津光生,John Begg,John Woodard

人工臓器 29(1) p.117 - 1172000/02-

高分子製人工弁の加速耐久試験確立に向けての力学的検討

岩清隆,梅津光生,井街宏,藤本哲男

人工臓器 29(2) p.489 - 4892000/03-

人工弁加速耐久試験のISO基準の拡張:高分子製人工弁への適用に関する検討

岩清隆,梅津光生,井街宏,藤本哲男

人工臓器 29(2) p.385 - 3852000/03-

Contribution of mechanical engineering to the field of artificial organs

Umezu M, Fujimoto T, Shiraishi Y, Iwasaki K, Kohno K, Arita M

Proceedings of inaugural Japan-Australia cardiovascular bioengineering meeting p.2 - 31999/03-

A new approch for the improvement of accelerated fatigue testing methodology

Iwasaki K, Umezu M, Kobayashi Y, Fujimoto T, Imachi K

Proceedings of inaugural Japan-Australia cardiovascular bioengineering meeting p.29 - 301999/05-

冠動脈ステントの力学的挙動試験

梅津光生,堀切芳一,岩崎清隆,藤本哲雄

人工臓器 29(1) p.99 - 992000/02-

有限要素法を用いたひずみ解析によるJellyfish弁のカルシウム沈着発生位置の検討

岩清隆,梅津光生,藤本哲男,井街宏

人工臓器 27(2) p.545 - 5501998-

Three types pf in vitro evaluation test system for blood pump performance

Umezu M, Fujimoto T, Shiraishi Y, Iwasaki K, Zhonggang Feng

ICBME/ISBMRE/JCCCAS’98, 第8回コンピュータ支援画像診断学会大会,第7回日本コンピュータ外科学会大会 p.1 - 21998/09-

Improvement of dynamic conditions in the accelerated fatigue testing for prosthetic heart valves

Iwasaki K, Umezu M, Wakui H, Kawada H, Fujimoto T, Imachi K

9th international conference on biomedical engineering p.342 - 3451997-

Development of a miniature undulation pump for the distributed artificial heart

Abe Y, Ono T, Isoyama T, Mochizuki S, Iwasaki K, Chinzei T, Saito I, Kouno A, Imachi K

Artificial Organs 24(8) p.656 - 6582000-

A step forward for the undulation pump total artificial heart

Abe Y, Chinzei T, Isoyama T, Ono T, Mochizuki S, Saito I, Iwasaki K, Ishimaru M, Baba A, Kouno A, Ozeki T, Tohyama T, Baba K, Imachi K

J of Artif Organs 3(2) p.70 - 742000-

Improvement of dynamic conditions in the accelerated fatigue testing for prosthetic heart valves

Iwasaki K, Umezu M, Wakui H, Kawada H, Fujimoto T, Imachi K

Proc. of the 9th International Conference on Biomedical Engineering p.342 - 3441997-

冠動脈ステントの力学的挙動試験

梅津光生, 堀切芳一, 岩清隆, 藤本哲男

人工臓器 29(1) p.99 - 104

耐久性向上を目指した高分子製人工心臓弁の開発とその総合的評価, ライフサポート

岩清隆

ライフサポート 11(2) p.12 - 141999-

Two Stenting at Coronary Artery Bifurcation Yields Slow-Flow Region at Carina: In vitro Pulsatile Flow Investigation Using Elastic 3-Dimensional Stenotic Bifurcated Artery Replica

Iwasaki, Kiyotaka;Yagi, Takanobu;Yamamoto, Tadashi;Yagishita, Yuichi;Shinke, Manabu;Noguchi, Yusuke;Takahashi, Sara;Umezu, Mitsuo

CIRCULATION 122(21) 2010-2010

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ISSN:0009-7322

Recent Perspective on Coronary Bifurcation Intervention: Statement of the "Bifurcation Club in KOKURA"

Murasato, Yoshinobu;Hikichi, Yutaka;Nakamura, Sunao;Kajiya, Fumihiko;Iwasaki, Kiyotaka;Kinoshita, Yoshihisa;Yamawaki, Masahiro;Shinke, Toshiro;Yamada, Shnichiro;Yamashita, Takehiro;Choo, Gim-Hooi;Nam, Chang-Wook;Kim, Young-Hak;Jepson, Nigel;Ferenc, Miroslaw

JOURNAL OF INTERVENTIONAL CARDIOLOGY 23(4) p.295 - 3042010-2010

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ISSN:0896-4327

Comparing Accuracy of Cerebral Aneurysm Size Measurements From Three Routine Investigations: Computed Tomography, Magnetic Resonance Imaging, and Digital Subtraction Angiography

Takao, Hiroyuki;Murayama, Yuichi;Ishibashi, Toshihiro;Saguchi, Takayuki;Ebara, Masaki;Arakawa, Hideki;Irie, Koreaki;Iwasaki, Kiyotaka;Umezu, Mitsuo;Abe, Toshiaki

NEUROLOGIA MEDICO-CHIRURGICA 50(10) p.893 - 8992010-2010

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ISSN:0470-8105

Neointimal Coverage Reduces a Potential Risk of Stent Separation of Sirolimus Eluting Stent: Accelerated Durability Tests Under in-vivo Simulated Cyclically-Bended Proximal Right Coronary Artery Environment

Iwasaki, Kiyotaka;Hikichi, Yutaka;Yamamoto, Tadashi;Kishigami, Sho;Arai, Jun;Noguchi, Yusuke;Kasanuki, Hirhoshi;Umezu, Mitsuo

CIRCULATION 124(21) 2011-2011

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ISSN:0009-7322

Assessment of a Novel Stentless Mitral Valve Using a Pulsatile Mitral Valve Simulator

Kasegawa, Hitoshi;Iwasaki, Kiyotaka;Kusunose, Shyunsuke;Tatusta, Ryota;Doi, Tetsuya;Yasuda, Hiroki;Umezu, Mitsuo

JOURNAL OF HEART VALVE DISEASE 21(1) p.71 - 752012-2012

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ISSN:0966-8519

Tensile Strength of Human Pericardium Treated with Glutaraldehyde

Yamashita, Hiromasa;Ozaki, Shigeyuki;Iwasaki, Kiyotaka;Kawase, Isamu;Nozawa, Yukinari;Umezu, Mitsuo

ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY 18(5) p.434 - 4372012-2012

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ISSN:1341-1098

Flexibility and Stent Fracture Potentials Against Cyclically Bending Coronary Artery Motions: Comparison Between 2-Link and 3-Link DESs.

Iwasaki, Kiyotaka;Kishigami, Sho;Arai, Jun;Ohba, Takafumi;Zhu, Xiaodong;Yamamoto, Tadashi;Hikichi, Yutaka;Umezu, Mitsuo

AMERICAN JOURNAL OF CARDIOLOGY 111(7) p.26B - 26B2013-2013

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ISSN:0002-9149

Prediction of Wall-thinning Area in Unruptured Intracerebral Aneurysms by Computational Fluid Dynamics

Hayashi, Yoshifumi;Yagi, Takanobu;Tobe, Yasutaka;Iwabuchi, Yuki;Yamanashi, Momoko;Takamura, Kenji;Iwasaki, Kiyotaka;Umezu, Mitsuo;Ishida, Takashi;Nakajima, Atsushi;Yoshida, Hirotaka;Nishitani, Kazutoshi;Ota, Yoshihisa;Sugawara, Michihito;Okada, Yoshifumi;Kubo, Toshiro;Kitahara, Shigemi

STROKE 44(2) 2013-2013

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ISSN:0039-2499

Fracture Potentials and Dynamic Flexibility of Peripheral Stents: Insights into Clinical Practice From Durability Tests Simulating Multi-loading Environments of Superficial Femoral and Popliteal Arteries

Iwasaki, Kiyotaka;Kishigami, Sho;Arai, Jun;Ohba, Takafumi;Tokutake, Hirotsugu;Zhu Xiaodong;Yagishita, Yuichi;Noguchi, Yusuke;Yamamoto, Tadashi;Hikichi, Yutaka;Umezu, Mitsuo

CIRCULATION 128(22) 2013-2013

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ISSN:0009-7322

Orbital Shaking Promoted Vascular Elastogenesis in Cultured Rat Aortic Smooth Muscle Cells

Shiraishi, Ryosuke;Iwasaki, Kiyotaka;Aida, Takashi;Saito, Shumpei;Zin, Nur Khatijah Mohd;Takeoka, Shinji;Umezu, Mitsuo;Minamisawa, Susumu

BIOPHYSICAL JOURNAL 106(2) p.615A - 615A2014-2014

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ISSN:0006-3495

Biomechanical Modeling to Improve Coronary Artery Bifurcation Stenting Expert Review Document on Techniques and Clinical Implementation

Antoniadis, Antonios P.;Mortier, Peter;Kassab, Ghassan;Dubini, Gabriele;Foin, Nicolas;Murasato, Yoshinobu;Giannopoulos, Andreas A.;Tu, Shengxian;Iwasaki, Kiyotaka;Hikichi, Yutaka;Migliavacca, Francesco;Chiastra, Claudio;Wentzel, Jolanda J.;Gijsen, Frank;Reiber, Johan H. C.;Barlis, Peter;Serruys, Patrick W.;Bhatt, Deepak L.;Stankovic, Goran;Edelman, Elazer R.;Giannoglou, George D.;Louvard, Yves;Chatzizisis, Yiannis S.

JACC-CARDIOVASCULAR INTERVENTIONS 8(10) p.1281 - 12962015-2015

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ISSN:1936-8798

Regulatory science of new technology: tendency of medical professionals' interests on silicone breast implants

Nakazaki, Tomomichi;Ikeda, Koji;Iwasaki, Kiyotaka;Umezu, Mitsuo

JOURNAL OF ARTIFICIAL ORGANS 19(3) p.283 - 2882016-2016

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ISSN:1434-7229

The effect of tendon stem/progenitor cell (TSC) sheet on the early tendon healing in a rat Achilles tendon injury model

Komatsu, Issei;Wang, James H-C.;Iwasaki, Kiyotaka;Shimizu, Ttsuya;Okano, Teruo

ACTA BIOMATERIALIA 42p.136 - 1462016-2016

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ISSN:1742-7061

In vitro evaluations of blood flow pattern in left ventricle on ventricular assist device

IGARASHI Toshihiro;KOKUZAWA Yuma;KUME Rei;KUSUNOSE Shunsuke;TATSUTA Ryota;YAGI Takanobu;IWASAKI Kiyotaka;YAMAZAKI Kenji;UMEZU Mitsuo

37(4) p.409 - 4122010/12-2010/12

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ISSN:09122664

Medical-Engineering Collaboration Operated by a Philosophy of Another EBM (Engineering Based Medicine)

UMEZU M.;IWASAKI K.;ISEKI H.;KASANUKI H.;PARK Y.;MURAGAKI Y.

14(3) p.188 - 1892012/10-2012/10

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ISSN:13449486

Investigation on the outlet boundary conditions of computational fluid dynamics for reproducing the flow distribution of the aorta

KONOURA C.;YAGI T.;NAKAMURA M.;IWASAKI K.;QIAN Y.;OKUDA S.;UMEZU M.

14(3) p.404 - 4052012/10-2012/10

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ISSN:13449486

Regenerative Medicine by Tissue-decellularization Technology

IWASAKI Kiyotaka

Journal of the Japan Society of Mechanical Engineers 117(1142) p.28 - 312014/01-2014/01

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ISSN:00214728

S021013 Investigation of tissue-degenerating hemodynamics in human cerebral aneurysms : correlation between bleb formation and flow impingement

YAGI Takanobu;HAYASHI Yoshifumi;TAKAHASHI Sara;TOBE Yasutaka;IWABUCHI Yuki;YAMANASHI Momoko;YAMAMOTO Tadashi;IWASAKI Kiyotaka;UMEZU Mitsuo;YOSHIDA Hirotaka;NISHITANI Kazutoshi;OHTA Yoshihisa;OKADA Yoshifumi;SUGAWARA Michihito;KUBO Toshiro;KITAHARA Shigemi

Mechanical Engineering Congress, Japan 2011p."S021013 - 1"-"S021013-4"2011/09-2011/09

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Outline:This study aimed to investigate "malignant hemodynamics" leading to induce the wall degradation of cerebral aneurysms in an effort to find out a reliable predictor as to which aneurysms were doomed to rupture. Two blister-holding aneurysms and two bleb-holding aneurysms were computationally analyzed and compared with those of aneurysmal appearances observed during operations. The results demonstrated that the sites of flow impingement and bifurcation were well correlated with those of blisters. Such a flow pattern was confirmed to be present at the neck of bleb. The inside of bleb was found to be dominated by weak regurgitation as a result of flow bifurcation. The possible scenario for the genesis and growth of bleb was proposed. Flow impingement was concluded to play a malignant role on aneurysmal wall degradation.

S021021 Development of a Decellularized Bovine Tendon for Anterior Cruciate Ligament Reconstruction

IWASAKI Kiyotaka;YOSHINAGA Takuto;YAMANO Toshiaki;HAYAKAWA Tomotaka;KANEKO Jo;OZAKI Shigeyuki;UMEZU Mitsuo

Mechanical Engineering Congress, Japan 2011p."S021021 - 1"-"S021021-3"2011/09-2011/09

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Outline:Autologous tendons or bone-patellar tendon-bone grafts are clinically used for reconstruction of anterior cruciate ligaments, because of unsatisfactory durability of synthetic materials. The aims of this study are to realize decellularization of 16-cm long xenogeneic tendons which have a potential to guide regeneration, and to investigate influences of decellularization on tissue mechanical properties. Bovine tendons were decellularized by combination of pulsatile flow-and-pressure circulation of 1 wt% deoxycholic acid and microwave radiation. Then, the tissues were additionally treated with endonuclease. Influences of decellularization on durability was investigated by a cyclic tensile test under 0-100 N loads. When the tissues were not ruptured, ultimate strength, elastic modulus, and ultimate strain were examined by a uniaxial tensile test. DNA of 16-cm long bovine tendons was successfully removed over 99.99% by our decellularization technology. Non-treated and decellularized tendons were not ruptured in 1000 cycles' tensile durability tests. After the cyclic tests, ultimate stress, elastic modulus, and ultimate strain of the decellularized tendons were comparable to those of non-treated tendons. We here reported, to our knowledge, the first successful decellularization of 16-cm long tendons with preserving mechanical integrity.

Advanced Medical Device and Regulatory Science

IWASAKI Kiyotaka

Journal of the Japan Society of Mechanical Engineers 118(1155) p.85 - 882015/02-2015/02

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ISSN:00214728

1B42 Development of a pulsatile flow simulator for the assessment of proper deployment of fenestrated stent grafts

ASATO Kenya;UEMATSU Miyuki;TANAKA Yoshinori;TAKAHASHI Yasuhiro;AZUMA Takashi;YAMAZAKI Kenji;NAKAOKA Ryusuke;NIIMI Shingo;UMEZU Mitsuo;IWASAKI Kiyotaka

2015(27) p.87 - 882015/01-2015/01

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1B43 Assessment of in vitro performance of a stentless mitral valve (Normo valve) using a pulsatile circulation system

HORIUCHI Yuki;IWASAKI Kiyotaka;MOON Sojung;KANAYA Kohei;UMEZU Mitsuo

2015(27) p.89 - 902015/01-2015/01

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1D12 Comparison of hemolytic property of two different pressure-loss oxygenators using the novel hemolysis test circuit

TAKAHASHI Azuma;IWASAKI Kiyotaka;MATSUHASHI Yuki;HIRATA Mayuki;YAMAMOTO Yoshiki;SUZUKI Sara;UMEZU Mitsuo

2015(27) p.137 - 1382015/01-2015/01

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1D13 Development of compact thrombogenicity test circuit for the coronary stent

MATSUHASHI Yuki;IWASAKI Kiyotaka;TAKAHASHI Azuma;HIRATA Mayuki;YAMAMOTO Yoshiki;SUZUKI Sara;UMEZU Mitsuo

2015(27) p.139 - 1402015/01-2015/01

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1D14 A proposal of evaluation criteria for anti-thrombogenicity of slow continuous hemofiltration devices

HIRATA Mayuki;IWASAKI Kiyotaka;MATSUHASHI Yuki;TAKAHASHI Azuma;NAGAI Mirei;UMEZU Mitsuo

2015(27) p.141 - 1422015/01-2015/01

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1E26 Development of a novel 5-DOF chuck for tensile test of anterior cruciate ligament

SAITO Shumpei;IWASAKI Kiyotaka;IMASU Hiroki;TAKANO Kazuya;UMEZU Mitsuo

2015(27) p.197 - 1982015/01-2015/01

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2A35 Study on relationship between minimum horizontal cross-sectional area at anastomosis and energy loss for development of anastomosis assessment feedback system

OYAMA Daisuke;PARK Young Kwang;YAGI Takanobu;IWASAKI Kiyotaka;OSAKA Shinichi;UMEZU Mitsuo

2015(27) p.329 - 3302015/01-2015/01

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2E33 Improvement of usability of navigation system for the treatment of aortic aneurysm by vascular prosthesis

TAKAHASHI Yasuhiro;UEMATSU Miyuki;AOMI Shigeyuki;IIMURA Hiroshi;NAKAOKA Ryusuke;NIIMI Shingo;SUZUKI Takashi;MURAGAKI Yoshihiro;ISEKI Hiroshi;UMEZU Mitsuo;IWASAKI Kiyotaka

2015(27) p.505 - 5062015/01-2015/01

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1A16 Development of a calcified aortic valve model for the assessment of paravalvular leak of transcatheter aortic valve

OBAMA Kazuto;FUKUYAMA Daiki;TAKAHASHI Azuma;AOYAMA Yusuke;TANAKA Yutaka;UMEZU Mitsuo;SAITO Shigeru;IWASAKI Kiyotaka

2016(28) p."1A16 - 1"-"1A16-5"2016/01-2016/01

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Outline:We aimed to develop a calcified aortic valve model for the evaluation of paravalvular leak of a transcatheter aortic valve. We fabricated a calcified aortic valve model using silicone based on a CT image of the pre-operation of the patient who received treatment with a transcatheter aortic valve. In addition, we fabricated a thoracic aorta model and an abdominal aorta model because these three dimensional morphology would affect the insertion procedure of the transcatheter valve. These models were installed into a chamber, and the other space of the models were filled with a glycerol solution with the refractive index and viscosity of 1.410±0.002 and 5.96 mPa・s respectively, in order to adjust the expansion rate of the valve annulus and to measure the expansion range by a lazer system in pulsatile flow and pressure environments. Using the test system, the maximum and minimum cross-sectional area of the valve annulus in systole and diastole in the pulsatile flow circuit could be adjusted to these in the referenced patients' data. The pulsatile flow system with patient specific aortic valve, thoracic aorta and abdominal aorta model would be useful to quantify the paravalvular leak performance of the transcatheter aortic valve.

1A22 Examination of the blood flow effects on the thrombus formation by real-time visualization using optical coherence tomography

MATSUHASHI Yuki;TAKAHASHI Azuma;HIRATA Mayuki;YAMAMOTO Yoshiki;SAMESHIMA Kei;AOYAMA Yusuke;UMEZU Mitsuo;IWASAKI Kiyotaka

2016(28) p."1A22 - 1"-"1A22-3"2016/01-2016/01

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Outline:Thrombus formations in medical devices are unsolved issue. If a reliable in vitro real-time visualization method is established, it will contribute the development and improvement of anti-thrombogenic medical devices. The aim of this study is to develop a real-time thrombus visualization system with an optical coherence tomography (OCT) and to reveal an influence of local blood flow on thrombus growth. We focus on the inlet and outlet part of connecters. The circuit was consisted of a roller pump, a reservoir, and resistance. The circuit volume was 50 ml. The blood flow rate and pressure were regulated to 100 ml/min and 70 mmHg. To visualize cross-sectional imaging of thrombus, we used a SS-OCT system with center wave-length of 1330 nm. OCT images were obtained every 10 minutes for 50 minutes. Test were performed 6 times. A fresh porcine whole blood with activated clotting time of approximately 200 sec was circulated. Thrombus-formed area increased with time at the outlet part of the connecter, however, the thrombus-formed area didn't increase at the inlet part. The part where thrombus-formed are increased was related to a flow-separation area. Flow-separation would be a cause to form such an increasingly thrombus. We revealed that the local blood flow is important not only for thrombus formation but also stability of thrombus-formed at the connecter.

1E42 Study on the relationship between modeling and energy loss of anastomotic configuration for anastomosis assessment

OYAMA Daisuke;PARK Young Kwang;YAGI Takanobu;IWASAKI Kiyotaka;OSAKA Shinichi;UMEZU Mitsuo

2016(28) p."1E42 - 1"-"1E42-4"2016/01-2016/01

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Outline:Off-pump CABG surgery requires high level of techniques. The surgeon must complete the anastomosis of two millimeter wide arteries within ten minutes on beating condition. Due to its difficulty, an effective training platform of DRY LAB with assessments is in strong need. This study investigated the models of anastomosis configurations and a relationship between the model and the energy loss (EL) using a beating heart simulator (BEAT, EBM) and coronary artery model (YOUCAN, EBM) which were developed from this research. The models for the analysis were chosen based on the actual EL; low (X: 42 μW), medium (Y: 196 μW) and high (Z: 362 μW) values. The effective cross-sectional areas were set by taking the cross-sectional areas from the mainstreams. The calculated EL was calculated using Hagen-Poiseuille because energy loss is inversely proportional to the square of the minimum effective cross-sectional area in a Hagen-Poiseuille flow. Results indicated that the change of the velocity distribution of the area in Y and Z were greater than those in X. The minimum effective cross-sectional areas were 2.1 mm^2 (X), 1.2 mm^2 (Y), 0.8 mm^2 (Z). Therefore, it was confirmed that mainstream could not utilize the anastomosis configuration efficiently in Y and Z. In addition, it was found that the calculated EL and the actual EL had a strong correlation, and the minimum effective cross-sectional area influenced the actual EL strongly.

1H45 Investigation of mechanical properties of Achilles' tendon autograft after ovine anterior cruciate ligament reconstruction

IMASU Hiroki;ITO Masafumi;TAKANO Kazuya;OKAMURA Akiyoshi;OKUDA Noriya;UMEZU Mitsuo;KATO Yoshiharu;IWASAKI Kiyotaka

2016(28) p."1H45 - 1"-"1H45-5"2016/01-2016/01

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Outline:We aimed to investigate mechanical properties of Achilles' tendon autograft after ovine anterior cruciate ligament reconstruction. Mature three female ovine were used in this study. In each ovine, the right knee underwent anterior cruciate ligament reconstruction. They were sacrificed at 13 weeks after surgery. In each ovine, both the knees were harvested, and the left knee was used to obtain the data of the native anterior cruciate ligament. Drawer test for stability evaluation and tensile test for evaluation of mechanical properties were performed. The knee was mounted on a jig with 5 degrees of freedom for tensile testing, four cycles of anterior-posterior shear loads (50 N) were applied to the knee at 30°, 60° and 90° of the flexion with a cross head speed set at 20 mm/min. The displacement of the femur relative to tibia was defined as the anterior-posterior translation of the knee. (1) Stress relaxation test (5 N, 10 min), (2) cyclic load test (0-50 N, 10 cycles, 10 mm/min), and (3) tensile test (300 mm/min) were performed in turn. Before each testing, tissue cross-sectional area was measured with the device using a laser displacement sensor. At 13 weeks after the implantation, the anterior-posterior translation of the reconstructed knee was greater than native anterior cruciate ligament. Ultimate strength and maximum Young's modulus of the femur-graft-tibia complex were smaller than native anterior cruciate ligament. These testing methods presented here is effective to gain insight into in vivo biomechanical remodeling of reconstructed tissues.

1H46 A study on time-dependent cell infiltration into the decellularized and sterilized bovine tendon in rat anterior cruciate ligament reconstruction

TAKANO Kazuya;ITO Masafumi;IMASU Hiroki;OKAMURA Akiyoshi;OKUDA Noriya;UMEZU Mitsuo;KATO Yoshiharu;IWASAKI Kiyotaka

2016(28) p."1H46 - 1"-"1H46-5"2016/01-2016/01

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Outline:In the treatment of anterior cruciate ligament rupture, anterior cruciate ligament reconstruction is performed using autologous tendon. However, there are problems in the invasiveness and limitation in the source of autologous tendon. In order to solve these problems, a decellularized and sterilized bovine tendon has been developed. The aim of this study is to investigate cell infiltration into the decellularized and sterilized bovine tendon in rat anterior cruciate ligament reconstruction. In 4 and 26 weeks after the implantation, the tissues were explanted and subjected to hematoxylin-eosin staining. In this study, rat autologous tendon were also implanted to compare cell infiltration into the reconstructed tissues between the decellularized and sterilized bovine tendon and rat autologous tendon In the implantation period of 4 weeks, the number of cells in the decellularized and sterilized bovine tendon was higher than that in the rat autologous tendon In the implantation period of 26 weeks, the number of cells in the decellularized and sterilized bovine tendon and that in the rat autologous tendon became comparable. In the implantation period of 26 weeks, the number of cells in the decellularized and sterilized bovine tendon and that in rat anterior cruciate ligament also became comparable. These data indicated that the decellularized and sterilized bovine tendon has a promise as a prosthesis for anterior cruciate ligament reconstruction.

2B14 Assessment of in vitro performance of a stentless mitral valve (Normo valve) using accelerated fatigue tests system

HORIUCHI Yuki;IWASAKI Kiyotaka;USUI Kazuaki;KASEGAWA Hitoshi;UMEZU Mitsuo

2016(28) p."2B14 - 1"-"2B14-5"2016/01-2016/01

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Outline:The aim of this study is to develop an accelerated fatigue tester for the Normo valve. Because the Normo valve has a unique structure similar to natural mitral valve, a novel accelerated fatigue tester which can mount the Normo valve and test in the condition recommended by the International Organization for Standardization (IS05840) was developed. We succeeded in producing the targeted closed duration percentage over the defined trans-valvular pressure gradient by adjusting the systolic and the drive frequency. The results showed that the drive condition of 10 Hz in drive frequency and 50% in systolic fraction met the requirement noted in ISO 5840.

2B15 Fatigue analysis on a self-expandable Nitinol stent deployed in femoral-popliteal artery under a multiple-load environment

TOKUTAKE Hirotsugu;IWASAKI Kiyotaka;ZHU Xiaodong;UMEZU Mitsuo

2016(28) p."2B15 - 1"-"2B15-3"2016/01-2016/01

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Outline:The purpose of this study is to investigate influences of multi-loads and stenosis in femoral-popliteal artery on fracture of self-expandable stent using finite element analysis. A nitinol alloy stent was selected. The three-dimensional CAD models of the stent and vessel were constructed using SolidWorks. First, the stent was compressed by four cylinder models. Second, the stent was deployed in 50%, 60% and 75% stenotic artery models. Third, cyclic multi-loads were applied to the artery model. Multi-loads were two types. One is shortening of 12.7% and torsion of 0.28 degree/mm (Average). Another is shortening of 6.9% and torsion of 0.14 degree/mm (Half of average). When average loads were applied, strain amplitude of stent were 0.61%, 0.75%, and 0.87% in 50%, 60% and 75% stenotic model. When half of average loads were applied, those were 0.36%, 0.41%, and 0.54%. According to constant-life diagrams of average loads, when the stent was deployed in over 60% stenotic artery model, risk of fracture was high. This study indicated that risk of fracture is increased by multi-loads and stenosis.

2B22 Development of the evaluation method of the thrombogenecity of continuous hemofiltration devices using human blood

HIRATA Mayuki;IWASAKI Kiyotaka;MATSUHASHI Yuki;TAKAHASHI Azuma;YAMAMOTO Yoshiki;SAMESHIMA Kei;AOYAMA Yusuke;UMEZU Mitsuo

2016(28) p."2B22 - 1"-"2B22-4"2016/01-2016/01

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Outline:Hemofilters are medical devices for assisting deteriorated renal functions, which purify the blood by removing pathogen and wastes. For continuous hemofilters, antithronbogenecity is one of the most important requirements. The aim of this study is to investigate the key parameters for the establishment of a reliable in vitro thrombogenecity testing methodology for continuous hemofilters using human blood from healthy volunteers. This study used adjusted activated clotting time of human blood drawn from healthy volunteers to 150-200 sec using heparin. The blood was circulated in the air-contactless circuit with flow and pressure in a clinical situation was reproduces. The tests were terminated when the inlet pressure elevated to 150 mmHg from the initiation pressure of 70 mmHg at the inlet. The average circulation duration was 6.5±1.7 hours(n=4). The circulation duration using human blood from healthy volunteers were shorter than using porcine blood which was previously reported. Hematocrit of porcine blood was lower than the human blood from healthy volunteers, whereas the hematocrit of porcine blood was comparable to dialysis patients. These data indicated the importance of hematocrit of blood in the assessment of the thrombogenecity of continuous hemofilters.

2B24 Experimental investigation of the influence of MPC coating on thrombus detachment from inflow cannula of EVAHEART

YAMAMOTO Yoshiki;IWASAKI Kiyotaka;MATSUHASHI Yuki;TAKAHASHI Azuma;HIRATA Mayuki;SAMESHIMA Kei;AOYAMA Yusuke;UMEZU Mitsuo

2016(28) p."2B24 - 1"-"2B24-4"2016/01-2016/01

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Outline:Thrombus formation at the interface between left ventricular wall and the inflow cannula of left ventricular assist device (LVAD) remains to be an unsolved problem that induces complications in clinical practice. The aim of this study is to develop an in vitro airless circuit which produces flow and pressure environments in patients with a LVAD, and to investigate an influence of MPC coating of the inflow cannula of EVAHEART^[○!R] LVAD (Sun Medical Technology Research Co., Japan) on thrombus detachment from the inflow cannula. In the thrombogenicity test, two identical circuits except for the cannula were prepared to form a comparative study. Heparinized blood from a single porcine with activated clotting time ranged within 130-210 sec was circulated for 4.5 hours. The tests were performed under the combinations of the total flow rate of 4 L/min or 5 L/min, and the pump rotational speed of 1800, 1900 or 2000 rpm, respectively. It was elucidated that higher amount of thrombus formed on the MPC non-coated cannula compared with MPC coated cannula. However, there was no difference in the amount of thrombus detached between the two cannula (Student's t-test, p=0.91). From these results, it was elucidated that the MPC non-coated cannula yielded significantly lower proportion of thrombus detachment to thrombus formation than the MPC coated cannula (Student's t-test, p<0.05).

2B25 Establishment of Non-clinical In Vitro Testing System and Methodology of Innovative Medical Devices for Approval : Facilitating Engineering Based Medicine

IWASAKI Kiyotaka;KASANUKI Hiroshi;ISEKI Hiroshi;NIIMI Shingo;HAISHIMA Yuji;MIYAZIMA Atsuko;KATO Reiko;SAKODA Hideyuki;UEMATSU Miyuki;MATSUHASHI Yuki;UMEZU Mitsuo

2016(28) p."2B25 - 1"-"2B25-5"2016/01-2016/01

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Outline:We have developed in vitro test methodologies modeling in vivo practical-use situations, to quantitatively assess safety and effectiveness of innovative medical devices. We believe that expediting development of these in vitro methodology not only reinforce preclinical evaluation and enhance timely access to innovative medical devices for patients but also reduce potential risk when used in real-world clinical practice, because controlled clinical trials have certain limitation in fully demonstrating benefit and risk. With the grant from Ministry of Health, Labour and Welfare intended for "Promotional Project for Practical Application of Innovative Pharmaceutical, Medical Device, and Tissue Engineering Products", we have developed drafts on in vitro test guideline for "Durability testing methods for coronary artery stent", "Durability testing methods for vascular stent intended for Superficial femoral - Popliteal artery", and "Method for in vitro thrombogenicity testing for inflow cannula of left ventricular assist system". Further 5 guideline drafts are under preparation. Here, we introduce impacts of in vitro test methods modeling in vivo intended-use situations on expediting availability of new medical devices and timely assessment and management of risk.

2F13 Development of a registration method using points of skeleton for navigation in blood vessel prosthesis replacement and error assessment using clinical data

TAKAHASHI Yasuhiro;UEMATSU Miyuki;AOMI Shigeyuki;IIMURA Hiroshi;NAKAOKA Ryusuke;NIIMI Shingo;SUZUKI Takashi;MURAGAKI Yoshihiro;ISEKI Hiroshi;UMEZU Mitsuo;IWASAKI Kiyotaka

2016(28) p."2F13 - 1"-"2F13-5"2016/01-2016/01

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Outline:We have developed a navigation system for the blood vessel prosthesis replacement of aortic aneurysms, and have used it in clinical practice. This system supports surgeons to identify a target intercostal artery by using patient image. The patient image and real body are matched by registration. Reference points of registration are anatomical landmarks of skeleton such as jugular notch, sternal angle, left anterior superior iliac spine, pubis, and spinous process. However, identification of spinous process was hard to doctors in operation. We developed a new registration method which X, Y and Z axis correspond to the Head-Foot, Right-Left and Anterior-Posterior directions. The specific feature is that identification of spinous process is not necessary. We evaluated errors with the new registration method using the retrospective 6 clinical data. We calculated fiducial localization error. As a result, errors of anterior points in the Head-Foot direction were less than 10 mm. We aimed to reduce the Head-Foot error as less than 20 mm because the ribs exist at intervals of approximately 40 mm in the Head-Foot direction. The new registration method was confirmed to be effective in the decision of approach to the target artery. Moreover, even when the point of the spinous process changed to the next spinous process of the set spinous processes, error was equivalent to the original point, therefore, using the present system, the identification of the spinous process can be unnecessary. It was concluded that newly-developed registration algorism is effective for doctors in identification of intercostal artery.

2F35 Investigation of strain measurement method in elastic blood vessel model using tomographic particle image velocimetry

TAKAHASHI Azuma;MATSUHASHI Yuki;SUZUKI Sara;AOYAMA Yusuke;UMEZU Mitsuo;IWASAKI Kiyotaka

2016(28) p."2F35 - 1"-"2F35-5"2016/01-2016/01

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Outline:Transcatheter aortic valve replacement (TAVI) is a less invasive therapy and the number of operations is increasing. In some operations of TAVI, valve annulus rupture and failure were happened. Strain measurement method in the blood vessel has not been established and there is no way to evaluate the strain distribution experimentally. It is difficult to measure large deformation of the blood vessel using conventional digital volume correlation with computed tomography. This study presents a new strain measurement method of an elastic blood vessel model using the displacement distribution measured by tomographic particle image velocimetry. Tracer particles were distributed in the blood vessel model and displacement distribution was measured by tracking the particles. The displacement measuring accuracy affected by the amount of displacement and spatial resolutions was assessed. The strain yielded in the blood vessel model, when it was 10% expanded, was measured in the optimal condition determined by the accuracy measurement. In this study, the optimal displacement spatial resolutions and displacement condition were 64 X 64 X 64 voxel^3 and 90-150 μm respectively. This experimental investigation revealed that the higher strain was yielded in the inner wall of the blood vessel model and the strain becomes lower toward the outer wall.

Clinical Results of Three-Time-Balloon-Inflation Method Performed in Elective PCI Cases

YAMAMOTO Tadashi;IWASAKI Kiyotaka;ARAI Jun;KITAHARA Shigemi;UMEZU Mitsuo

BME 51(6) p.350 - 3562013-2013

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ISSN:1347-443X

Outline:Percutaneous coronary intervention (PCI) for ischemic heart disease became a common therapy. The improvement of treatment results was caused by invention of drug-eluting stent (DES) but its implantation procedure for pressure and inflation time has not been discussed. 3-time-balloon-inflation method is proved to be an effective method for inflation in in vitro experiments and it was practiced in the clinical field. The purpose of this study is to determine the effectiveness of the 3-time-balloon-inflation method and investigate the factors that cause suppression of stent expansion. From January 2011 to March 2012, PCI with drug-eluting stent (XIENCE V) were performed to 169 patients by a single-operator with 3-time-ballon-inflation method. Minimal lumen area (MLA), vessel cross-sectional area, and plaque cross-section in the MLA were measured by intravascular ultrasound (IVUS) before stent implantation. Minimum stent area (MSA) was measured after stent implantation. Stent expansion ratio (SER) was calculated from assumed area and MSA. Area acquisition ratio (AAR) was calculated from MSA and MLA. Subsequently, the ratio of calcification in the lesion was measured using the color mapping function mounted on the IVUS. The stent diameter used in this study was 2.89±0.35[mm] (mean±SD), stent length was 20.5±6.2[mm] (mean±SD), and the stent expansion pressure was 10.3±2.4[atm] (mean±SD). There was no difference in SER by stent size, target vessels, and MLA. Significant difference was seen in the calcification ratio between the group without pre-dilatation (n=27) and the group with pre-dilatation (n=142), but no difference in SER between the two groups. It was suggested that calcification ratio is one of the factors that causes the suppression of stent expansion because significance of calcification ratio came out in AAR.

Durability Test for Implantable Left Ventricle Assist System EVAHEART

KITANO Tomoya;MIYAKOSHI Takayuki;KOBAYASHI Shinji;TOKUNO Toshimasa;YAMAZAKI Kenji;IWASAKI Kiyotaka;UMEZU Mitsuo

BME 49(6) p.918 - 9242011-2011

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ISSN:1347-443X

Outline:A durability test of the implantable Left Ventricular Assist System EVAHEART was conducted to demonstrate that the EVAHEART Blood Pump can be run for 2 years without failing. This testing was useful to indicate potential for BTT and possibly DT applications. We developed a custom durability test mock circulation loop which generates a pulsatile flow simulating the native left ventricle. This mock circulation loop includes components which mimic the left ventricle (LV chamber) and compliance in the aorta (aortic column), and a loop which connects the blood pump to both the LV chamber (inlet) and the aortic column (outlet). The LV chamber has two one-way valves and a linear motor connected to a rolling seal, allowing it to generate pulsatile flow. The blood pump speed was tuned to achieve clinically relevant flow, based on the need to supplement a failing heart. The simulated heart rate (stroke rate of the linear actuator) cycled through 3 different settings each day to simulate changes in patient activity level. The sample size for the durability test was set to 18, and the test duration was 2 years. During the test, no critical blood pump failures were observed. There were no indications of significant decrease in pump performance or seal performance. Furthermore, no symptoms of failure, such as abnormal wear, were observed. In conclusion, the durability test successfully demonstrated that the EVAHEART Blood Pump achieved component reliability at a minimum of 90% reliability and 88% confidence interval over a mission life of two years.

Systematic Analysis of the Incidence of Coronary Stent Fracture and Adverse Events in Japan

MATSUI Yutaka;UMEZU Mitsuo;KASANUKI Hiroshi;IWASAKI Kiyotaka

Regulatory Science of Medical Products 6(1) p.1 - 102016-2016

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ISSN:2185-7113

Outline:Coronary stent fracture (SF) is recognized as a risk of restenosis or stent thrombosis. However, the actual incidence is unclear in real world clinical settings in Japan. This study aims to estimate the incidence of SF in Japan by surveying peer-reviewed journals, and to elucidate the actual situation of adverse event reports. We conducted literature analysis regarding the incidence of SF using PubMed and ICHUSHI on April 1 2014. For PubMed, the term "stent fracture" was used. For ICHUSHI, "coronary artery" (in Japanese), "stent" (in Japanese), "fracture" (in English), "fracture" (in Japanese), and "damage" (in Japanese) were used. PubMed search initially yielded 895 papers. Of these, 792 studies had been conducted in countries outside of Japan, 45 studies were related to non-coronary artery, 17 studies did not deal with incidences of SF, and 11 studies targeted duplicated cases during the same implantation period. After these studies were excluded, we analyzed 30 remaining papers comprising 14 observational studies and 16 case reports. There were 643 SF cases in the scientific papers and 105 SF cases in the adverse event reports. Through the 14 observational studies, the SF incidence was estimated as 5.4% (595/10,927 lesions). We found a significant difference in SF incidences between the paper and adverse event report (6.1-hold). These data indicated that the adverse event report showed a partial picture of the real situation.

Analysis of Medical Device Recalls Owing to Output Information from Software

KITAWAKI Ryota;UMEZU Mitsuo;IWASAKI Kiyotaka;KASANUKI Hiroshi

Regulatory Science of Medical Products 6(3) p.281 - 2932016-2016

CiNii

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ISSN:2185-7113

Outline:

Because software as a medical device (SaMD) does not come into direct contact with patients, it does not pose such direct harm as that caused by conventional hardware medical devices (non-SaMD) ; however, SaMD does present indirect harm. Using US recall data, the objective of this study was to investigate indirect harm caused by software medical devices including both SaMD and non-SaMD. We collected recall data in which the cause was determined by the US Food and Drug Administration to be software design, and we determined whether the product in each recall was SaMD or not (non-SaMD). We also classified the failure mode of each recall into four groups : physical (Group 1) ; information-related (Group 2), data-related (Group 3) ; and other (Group 4). We identified 6,393 recalls for 2009-2014, and 712 software-caused recalls. Of those, the leading failure mode was Group 2 that can lead to indirect harm and accounted for 408 (57%), followed by Group 1 that can lead to direct harm and accounted for 122 (17%). Of 408 Group 2 recalls, 387 (95%) were recall class Ⅱ and 6 (1%) were recall class Ⅰ. Of the 6, 4 were for non-SaMD and 2 were for SaMD. The findings revealed by this study indicate the importance of the further understanding of safety of information presentation functionality and the necessity of further discussion of safety measures.

Usability improvement on an intraoperative navigation system for open surgical repair of thoracic and thoracoabdominal aortic aneurysm

Uematsu Miyuki;Aomi Shigeyuki;Yamazaki Kenji;Iwasaki Kiyotaka;Nakaoka Ryusuke;Niimi Shingo;Suzuki Takashi;Muragaki Yoshihiro;Iseki Hiroshi

Transactions of Japanese Society for Medical and Biological Engineering 54(26) p.S17 - S172016-2016

CiNii

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Outline:

A navigation system with high accuracy is required for performing precise surgery. To obtain high accuracy, three factors should be considered: acquiring precise image data of patient, measuring an accurate intraoperative patient position and reducing registration error. Although it spends a lot of efforts to set up the system during surgery, its performance does not always satisfy surgeons.

During this decade, we have developed a surgical navigation system for aortic aneurysm repair and utilized it in one hundred clinical cases. It has been found that this system has needed to improve the usability and the reliability in registration process to show valuable information for surgery. Our recent system adopts a two-phased approach with different goals. Before thoracotomy, it exhibits the location of a target intercostal artery in the thorax and supports a surgeon to determine an appropriate approach to repair aortic aneurysm in each patient setup and anatomy. After adhesiolysis, it narrows the range of existing area of the artery within five millimeters and assists him to identify the artery.

In 2016, its improved system is ready to use for clinical pre-trial with approval from Hospital Ethics Committee of Tokyo Women's Medical University. In the next two years, it is hoped that the improved system provides the clinical benefit.

Six-case reports in clinical trials on a new surgical navigation system for thoracic and thoracoabdominal aortic aneurysm

Uematsu Miyuki;Aomi Shigeyuki;Yamazaki Kenji;Iwasaki Kiyotaka;Umezu Mitsuo;Nakaoka Ryusuke;Haishima Yuji;Suzuki Takashi;Muragaki Yoshihiro;Iseki Hiroshi

Transactions of Japanese Society for Medical and Biological Engineering 55(5) p.434 - 4342017-2017

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Outline:

We have been developing a surgical navigation system to support a surgeon to identify the anatomical orientation. Its first prototype was designed in 2004 and clinically tested in 2006. During this decade, we have utilized it in one hundred clinical cases. Learned through trial and error, it was found that this system needed to improve the usability and the reliability in registration process to show valuable information for surgery. Our improved system was approved to use for clinical pre-trial from Hospital Ethics Committee of Tokyo Women's Medical University (160402), and it was utilized for six cases from June 2016 to January 2017. The new system worked suitably compared with the former one. As for spending time on the new system, it took 9.8±1.7 minutes before thoracotomy and 6.4±1.5 minutes after adhesiolysis. Target arteries were determined smoothly in all cases. We hope that widespread use of the system would be promoted.

Assessment of a novel stentless mitral valve using a pulsatile mitral valve simulator.

Kasegawa Hitoshi;Iwasaki Kiyotaka;Kusunose Shyunsuke;Tatusta Ryota;Doi Tetsuya;Yasuda Hiroki;Umezu Mitsuo

Assessment of a novel stentless mitral valve using a pulsatile mitral valve simulator. 21(1) 2012-2012

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ISSN:0966-8519

Outline:BACKGROUND AND AIM OF THE STUDY:The study aim was to develop a novel stentless mitral valve (SMV) and to evaluate its performance, using an original pulsatile simulator developed specifically to analyze the hydrodynamic function of the mitral valve.;METHODS:The SMV developed at the authors' institution consists of two major components: a large anterior leaflet with commissures, and a small posterior leaflet. The valve is formed by suturing the leaflets (made from bovine pericardium) to a flexible (Duran) ring. The SMV, constructed with a 27 mm flexible ring, was installed into the mitral valve simulator, after which the four papillary flaps of the two leaflets were sutured to artificial papillary muscles. The artificial ventricle was driven pneumatically at a pulse rate of 70 beats/min, with a systolic fraction of 35%. The mean flow, aortic pressure, and atrial pressure were adjusted to 4.5 1/min, 120/80 mmHg, and 10 mmHg, respectively. A 27 mm mechanical valve (MEV; St. Jude Medical Inc.) was employed as a control. The hydrodynamic performance of the SMV and MEV were investigated and compared. An echo-Doppler study was also performed.;RESULTS:The waveforms of the SMV and MEV showed a similar pattern. The mean transvalvular flow was 4.7 +/- 0.4 1/min for the SMV, and 3.55 +/- 0.13 1/min for the MEV (p < 0.001). Mitral regurgitation was 5.07 +/- 1.15 and 3.78 +/- 0.35 ml/beat, respectively (p < 0.05). Echocardiographic data indicated that the regurgitant jet towards the left atrial model was none or trivial for the SMV, and trivial for the MEV.;CONCLUSION:Within the environment of the mitral valve simulator, the novel SMV prepared from bovine pericardium demonstrated excellent performance characteristics, and may represent a potential future alternative for bioprosthetic stented mitral valves.

Time series analysis of the effectiveness and safety of capsule endoscopy between the premarketing and postmarketing settings: A meta-analysis

Iijima, Kazuo; Umezu, Mitsuo; Iwasaki, Kiyotaka; Iwasaki, Kiyotaka

PLoS ONE 11(6) 2016/06-2016/06

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Outline:© 2016 Iijima et al.Background Clinical studies for assessing the effectiveness and safety in a premarketing setting are conducted under time and cost constraints. In recent years, postmarketing data analysis has been given more attention. However, to our knowledge, no studies have compared the effectiveness and the safety between the pre- and postmarketing settings. In this study, we aimed to investigate the importance of the postmarketing data analysis using clinical data. Methods and Findings Studies on capsule endoscopy with rich clinical data in both pre- and postmarketing settings were selected for the analysis. For effectiveness, clinical studies published before October 10, 2015 comparing capsule endoscopy and conventional flexible endoscopy measuring the detection ratio of obscure gastrointestinal bleeding were selected (premarketing: 4 studies and postmarketing: 8 studies) from PubMed (MEDLINE), Cochrane Library, EMBASE and Web of Science. Among the 12 studies, 5 were blinded and 7 were non-blinded. A time series meta-analysis was conducted. Effectiveness (odds ratio) decreased in the postmarketing setting (premarketing: 5.19 [95% confidence interval: 3.07-8.76] vs. postmarketing: 1.48 [0.81-2.69]). The change in odds ratio was caused by the increase in the detection ratio with flexible endoscopy as the control group. The efficacy of capsule endoscopy did not change between pre- and postmarketing settings. Heterogeneity (I2 ) increased in the postmarketing setting because of one study. For safety, in terms of endoscope retention in the body, data from the approval summary and adverse event reports were analyzed. The incidence of retention decreased in the postmarketing setting (premarketing: 0.75% vs postmarketing: 0.095%). The introduction of the new patency capsule for checking the patency of the digestive tract might contribute to the decrease. Conclusions Effectiveness and safety could change in the postmarketing setting. Therefore, time series meta-analyses could be useful to continuously monitor the effectiveness of medical device in clinical practices.

Analysis of the safety evaluation for premarketing clinical trials of hemodialyzer and of postmarketing safety reports of hemodialyzer in Japan and the US: insights into the construction of a sophisticated premarketing evaluation

Saito, Masami; Iwasaki, Kiyotaka; Iwasaki, Kiyotaka

Journal of Artificial Organs 20(1) p.62 - 702017/03-2017/03

PubMedDOIScopus

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ISSN:14347229

Outline:© 2016, The Japanese Society for Artificial Organs. Our aim was to conduct a scoping review of the regulations for hemodialyzers in the safety evaluation in Japan and the United States, and to evaluate the criteria for premarketing clinical trials and postmarketing safety reports to inform the development of a sophisticated premarketing evaluation in Japan. Regulations for approval of hemodialyzers were identified from the databases of the Ministry of Health, Labor and Welfare in Japan and the Federal Drug Agency (FDA) in the United States (US). The criteria for premarket clinical trials and postmarketing safety reports were evaluated for both countries. Standards in Japan required evaluation of blood compatibility and reporting of acute adverse effects by a premarketing clinical trial in 6 of 86 applications with semipermeable membrane materials deemed to be different to those of previously approved devices from 1983 to 31 August 2015. By comparison, the clinical trial was required in one of 545 approvals in the US from 1976 to 29 January 2016, but blood compatibility was not the point. All postmarketing adverse effects identified in Japan were included in the set of ‘warnings’. The more stringent requirements for evaluation of blood compatibility and acute adverse effects in Japan seemed to be related to differences in the history of quality management systems for medical devices between the two countries. This study revealed that there were differences between Japan and the US in requiring the premarketing clinical trials for the hemodialyzers. Our findings could be useful for constructing sophisticated premarketing safety evaluation.

Reduction in incomplete stent apposition area caused by jailed struts after single stenting at left main bifurcation lesions: micro-CT analysis using a three-dimensional elastic bifurcated coronary artery model

Hikichi, Yutaka; Hikichi, Yutaka; Umezu, Mitsuo; Umezu, Mitsuo; Node, Koichi; Iwasaki, Kiyotaka; Iwasaki, Kiyotaka

Cardiovascular Intervention and Therapeutics 32(1) p.12 - 172017/01-2017/01

PubMedDOIScopus

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ISSN:18684300

Outline:© 2016, The Author(s).Stent struts protruding into ostial side branch called “jailed strut” at bifurcation lesions is a likely cause of thrombus formation. We aimed to investigate the influences of multiple kissing balloon inflation (KBI) for stent expansion, and stent platform design, respectively, on the reduction of incomplete stent apposition area (ISA area) caused by jailed struts at a side-branch ostium, using a three-dimensional elastic left main (LM) bifurcated coronary artery model. The referenced LM bifurcation angle data of 209 patients were stratified by tertiles focusing on the angle between the LM trunk (LMT) and left anterior descending artery (LAD). A bifurcation model was fabricated with angles of 129°, 122.2°, and 76.4° for LMT–LAD, LMT–left circumflex (LCx), and LAD–LCx, respectively, and with diameters of 5, 3.75, and 3.5 mm for LMT, LAD, and LCx, respectively; these diameters fulfill Murray’s law. A 75 % stenosis was included along the LMT. One-time and three-time KBIs were conducted using two-link Nobori and three-link Xience Xpedition (n = 6 each). The ISA area was quantified using micro-CT. Three-time KBI was effective in reducing the ISA area compared with one-time KBI for both the Nobori (p = 0.05) and Xience Xpedition (p = 0.07). The ISA area was smaller in the Nobori than in the Xience Xpedition, both in one-time and three-time KBI (one-time KBI: p = 0.003; three-time KBI: p = 0.001). Our findings of this study on reducing the ISA area by focusing on an interventional technique and stent design may help to improve coronary bifurcation intervention for a possibly better long-term clinical outcome.

Investigation of the influence of fluid dynamics on thrombus growth at the interface between a connector and tube

Matsuhashi, Yuki; Sameshima, Kei; Yamamoto, Yoshiki; Umezu, Mitsuo; Umezu, Mitsuo; Iwasaki, Kiyotaka; Iwasaki, Kiyotaka

Journal of Artificial Organs 20(4) p.293 - 3022017/12-2017/12

DOIScopus

Detail

ISSN:14347229

Outline:© 2017, The Author(s). Thrombus formation at the interface between connectors and tubes is a potential risk factor for complications. We investigated time-dependent relationships between formation of thrombus and hemodynamic factors at the interface between connectors and tubes using optical coherence tomography (OCT) under pulsatile flow. A swept-source OCT with the center wavelength of 1330 nm was employed. The sequential process of thrombus formation at the interface of connectors and tubes in the inlet and outlet was investigated. Connectors with and without tapers were tested using identical 50-ml air-contactless circuits. Fresh human blood from healthy volunteers was circulated under pulsatile flow. Thrombus initially formed at the interface between the connector tip and the tube. Geometries of thrombus growth were different between the 2 connectors, and between the inlet and the outlet. Growth of thrombus was observed at the interface between the connectors and tubes over time in 60 min circulation, except at the outlet part of connector without tapers. At the connector without tapers outlet, thrombus propagation length from the connector edge toward the flow downstream was comparable at 10 and 60 min (0.55 ± 0.35 vs. 0.51 ± 0.32 mm, p = 0.83). Analysis using particle image velocimetry showed the presence of a flow reattachment point 1.5 mm downstream from the connector edge. These results suggest that the flow reattachment point inhibits downstream thrombus growth. We quantitatively demonstrated sequential thrombus process at the interface between the connectors and tubes under pulsatile flow of human blood using OCT.

A three-dimensional strain measurement method in elastic transparent materials using tomographic particle image velocimetry

Takahashi, Azuma; Suzuki, Sara; Aoyama, Yusuke; Umezu, Mitsuo; Umezu, Mitsuo; Iwasaki, Kiyotaka; Iwasaki, Kiyotaka; Iwasaki, Kiyotaka

PLoS ONE 12(9) 2017/09-2017/09

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Outline:© 2017 Takahashi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background: The mechanical interaction between blood vessels and medical devices can induce strains in these vessels. Measuring and understanding these strains is necessary to identify the causes of vascular complications. This study develops a method to measure the three-dimensional (3D) distribution of strain using tomographic particle image velocimetry (Tomo-PIV) and compares the measurement accuracy with the gauge strain in tensile tests. Methods and findings: The test system for measuring 3D strain distribution consists of two cameras, a laser, a universal testing machine, an acrylic chamber with a glycerol water solution for adjusting the refractive index with the silicone, and dumbbell-shaped specimens mixed with fluorescent tracer particles. 3D images of the particles were reconstructed from 2D images using a multiplicative algebraic reconstruction technique (MART) and motion tracking enhancement. Distributions of the 3D displacements were calculated using a digital volume correlation. To evaluate the accuracy of the measurement method in terms of particle density and interrogation voxel size, the gauge strain and one of the two cameras for Tomo-PIV were used as a video-extensometer in the tensile test. The results show that the optimal particle density and interrogation voxel size are 0.014 particles per pixel and 40 × 40 × 40 voxels with a 75% overlap. The maximum measurement error was maintained at less than 2.5% in the 4-mm-wide region of the specimen. Conclusions: We successfully developed a method to experimentally measure 3D strain distribution in an elastic silicone material using Tomo-PIV and fluorescent particles. To the best of our knowledge, this is the first report that applies Tomo-PIV to investigate 3D strain measurements in elastic materials with large deformation and validates the measurement accuracy.

Real-time visualization of thrombus formation at the interface between connectors and tubes in medical devices by using optical coherence tomography

Matsuhashi, Yuki; Sameshima, Kei; Yamamoto, Yoshiki; Umezu, Mitsuo; Umezu, Mitsuo; Iwasaki, Kiyotaka; Iwasaki, Kiyotaka; Iwasaki, Kiyotaka

PLoS ONE 12(12) 2017/12-2017/12

PubMedDOIScopus

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Outline:© 2017 Matsuhashi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background: Blood-contacting devices have contributed to improving the treatment of patients. However, thrombus formation at the interface between a connector and tube is still a potential source of thrombus-related complications that induce stroke or myocardial infarction. We aimed to develop a non-blood-contacting real-time method for visualizing thrombus formation, and to experimentally investigate the time-dependent phenomenon of thrombus formation at the interface between a connector and a tube in a medical device. Methods and findings: An optical coherence tomography device with a center wavelength of 1330 nm was used to visualize thrombus formation during porcine blood circulation for 50 min in a closed 50-mL circulation system isolated from ambient air. The thrombus formation sites at the interface between a tube and connector were visualized. The area of the thrombus formation at the interface between the inlet of the connector and the tube was found to be 0.012 ± 0.011 mm 2 . Conversely, at the interface between the outlet of the connector and the tube, the area was found to be 0.637 ± 0.306 mm 2 . Thus, significantly larger amounts of thrombus were formed at the outlet interface (p < 0.01). The thrombus formation area at the outlet interface increased over time. Conversely, the area of thrombus formation showed repeated increasing and decreasing behavior at the inlet interface. Flow visualization with particle image velocimetry showed the presence of a flow separated area in the minimal f low phase at the inlet interface and a large recirculating slow flow region at the outlet interface in the minimal flow phase. These data suggested that the recirculating stagnant flow region contributed to thrombus growth. Conclusions: The method presented here was effective in quantitatively assessing time-dependent phenomena of thrombus formation at the connector-tube interface. The method may contribute to the assessment of thrombogenicity of a novel design of connector.

A proctoring system to manage the learning curve associated with the introduction of transcatheter aortic valve implantation in Japan

Yamawaki, Masahiro; Yamawaki, Masahiro; Iwasaki, Kiyotaka; Araki, Motoharu; Ito, Tsutomu; Ito, Yoshiaki; Tada, Norio; Takagi, Kensuke; Yamanaka, Futoshi; Watanabe, Yusuke; Yamamoto, Masanori; Yamamoto, Masanori; Shirai, Shinichi; Hayashida, Kentaro

Heart and Vessels p.1 - 102017/12-2017/12

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ISSN:09108327

Outline:© 2017 Springer Japan KK, part of Springer Nature As transcatheter aortic valve implantation (TAVI) requires multidisciplinary collaboration, operators and the entire heart team must overcome a steep learning curve. A web-based screening and traditional on-site proctoring system were developed for the introduction of TAVI in Japan. To assess the learning curve involved with the introduction of TAVI under the supervision of a novel proctoring system. We divided 749 consecutive patients enrolled in the OCEAN-TAVI study between October 2013 and August 2015 into the trans-femoral (TF, n = 608) and transapical (TA, n = 141) approach groups to compare outcomes in patients who underwent TAVI during the early proctoring period (proctoring group) and after the procedures began to be performed independently (independent group). The primary endpoint was the rate of composite events regarding early safety (at 30 days) according to the valve academic research consortium-2 criteria. For TF-TAVI, the logistic EuroSCORE and the rate of peripheral artery disease were significantly lower during the independent period. The rate of device success significantly increased during the independent period (90.5 vs. 81.8%, p = 0.005). The rate of the primary endpoint was significantly reduced during the independent period compared to that during the proctoring period for TA-TAVI (21.3 vs. 37.9%, p = 0.031); however, no difference was observed for TF-TAVI (16.8 vs. 13.1%, p = 0.283). No deaths occurred within 30 days during the proctoring period for TF-TAVI. After adjustment using propensity score matching, the procedure time for TF-TAVI (88 ± 43 vs. 102 ± 36 min, p = 0.004) and the rate of life-threatening bleeding for TA-TAVI (3.6 vs. 25%, p = 0.026) reduced during the independent period compared to the values during the proctoring period. During the introduction of TAVI under the supervision of a new proctoring system in Japan, clinical outcomes and technical aspects improved significantly. There are differences in the steepness of the learning curve between TF-TAVI and TA-TAVI.

Investigation of adverse events associated with an off-label use of arterial stents and CE-marked iliac vein stents in the iliac vein: insights into developing a better iliac vein stent

Shida, Takuya; Umezu, Mitsuo; Umezu, Mitsuo; Iwasaki, Kiyotaka; Iwasaki, Kiyotaka

Journal of Artificial Organs p.1 - 72018/02-2018/02

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ISSN:14347229

Outline:© 2018 The Japanese Society for Artificial Organs We analyzed the adverse events associated with an off-label use of arterial stents and CE-marked iliac vein stents for the treatment of iliac venous thromboembolism and investigated their relationships with the anatomical features of the iliac vein, to gain insights into the development of a better iliac vein stent. Reports of adverse events following the use of stents in the iliac vein were retrieved from the Manufacturer and User Facility Device Experience (MAUDE) database that contain suspected device-associated complications reported to the Food and Drug Administration. Data from 2006 to 2016 were investigated. The literature analysis was also conducted using PubMed, Cochrane Library, EMBASE, and Web of Science focusing on English articles published up to 4 October 2016. The analysis of 88 adverse events from the MAUDE database and 182 articles from the literature revealed that a higher number of adverse events had been reported following the use of arterial stents in the iliac vein compared to CE-marked iliac vein stents. While stent migration and shortening were reported only for the arterial stents, stent fracture and compression occurred regardless of the stent type, even though a vein does not pulsate. A study of the anatomical features of the iliac vein implies that bending, compression, and kink loads are applied to the iliac vein stents in vivo. For designing, developing, and pre-clinical testing of stents intended for use in the iliac vein, the above mechanical load environments induced by the anatomical features should be considered.

Bench testing and coronary artery bifurcations: A consensus document from the European Bifurcation Club

Ormiston, John A.; Ormiston, John A.; Ormiston, John A.; Kassab, Ghassan; Finet, Gerard; Chatzizisis, Yiannis S.; Foin, Nicholas; Mickley, Timothy J.; Chiastra, Claudio; Murasato, Yoshinobu; Hikichi, Yutaka; Wentzel, Jolanda J.; Darremont, Olivier; Iwasaki, Kiyotaka; Lefèvre, Thierry; Louvard, Yves; Beier, Susann; Hojeibane, Hikmat; Netravali, Ashley; Wooton, Jeffery; Cowan, Brett; Webster, Mark W.; Medrano-Gracia, Pau; Medrano-Gracia, Pau; Stankovic, Goran

EuroIntervention 13(15) p.e1794 - e18032018/02-2018/02

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ISSN:1774024X

Outline:© Europa Digital & Publishing 2018. All rights reserved. This is a consensus document from the European Bifurcation Club concerning bench testing in coronary artery bifurcations. It is intended to provide guidelines for bench assessment of stents and other strategies in coronary bifurcation treatment where the United States Food and Drug Administration (FDA) or International Organization for Standardization (ISO) guidelines are limited or absent. These recommendations provide guidelines rather than a step-by-step manual. We provide data on the anatomy of bifurcations and elastic response of coronary arteries to aid model construction. We discuss testing apparatus, bench testing endpoints and bifurcation nomenclature.

Books And Publication

人工臓器で幸せですか?(梅津光生編)『心臓弁膜症と治療』

岩﨑清隆

コロナ社2005/10-

人工弁、生命・医療・福祉ハンドブック

岩﨑清隆

コロナ社2007/02-

拍動循環バイオリアクター:動脈血管の創生、再生医療のための培養システム

岩﨑清隆

CMC出版2010/01-

先端医療シリーズ43 循環器疾患の最新医療 人工心臓弁

岩﨑清隆

寺田国際事務所/先端医療技術研究所2012/10-

理工学の立場からの医工学人材育成

岩﨑清隆、梅津光生

Biophilia2013-

心臓弁の再生—体内で自己細胞により再生・自己化を誘導する無細胞化心臓弁の創生—

岩﨑清隆

再生医療技術の最前線・CMC出版2007/05-

再生医療、生命・医療・福祉ハンドブック

岩﨑清隆

2007/02-

人工臓器の非臨床性能評価法の開発

岩﨑清隆

2008/07-

Lecture And Oral

先進的医療機器の迅速な実用化と安全な普及を促進する非臨床評価試験法の進展

岩﨑清隆

2015/09/05

Detail

Oral presentation(general)

有限要素解析を用いた繰り返し屈曲下での冠動脈ステントの疲労破断予測

岩﨑清隆

2015/05/07

Detail

Oral presentation(general)

先進医療機器開発と普及のための医工学的非臨床評価法の進展

岩﨑清隆

2014/11/02

Detail

Oral presentation(general)

体組織無細胞化技術と組織滅菌技術による膝前十字靭帯再建デバイスの開発

岩﨑清隆

2014/10/18

Detail

Oral presentation(general)

下肢ステントと血管に生じる力学的負荷環境

岩﨑清隆

2014/10/04

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Oral presentation(general)

The Ultimate DES has Arrived 〜PREMIER® Performance〜

2014/07/25

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Oral presentation(general)

Fracture potentials and dynamic flexibility of peripheral stents: Insights into clinical practice from durability tests simulating multi-loaing environments of superficial femoral and popliteal arteries

American Heart Association Scientific Session 20132013/11/17

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Oral presentation(general)

Comparison of flexibility and stent fracture potentials against cyclically bending coronary artery motions between2-link and 3-link DES

EuroPCR(Percutaneous Coronary Revascularization) 20132013/05/21

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Oral presentation(general)

Flexibility and Stent Fracture Potensials Against Cyclically Bending Coronary Artery Motion: Comparison Between 2-Link and 3-Link DESs

TCTAP(Tokyo Percutaneous cardiovascular Intervention Conference) 20132013/04/23

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Oral presentation(general)

Bending flexibility of Stents: Comparison among four different DES platforms with different design and materials deployed in in-vivo simulated cyclically-bending coronary artery model

American Heart Association Scientific Session 20122012/11

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Oral presentation(general)

Decellularized and sterilized xenogeneic tissues inhibit complement and neutrophil activation: In vitro investigation using a novel blood-compatibility screening system

3rd Termis World Congress2012/09

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Oral presentation(general)

Neointimal coverage reduses a potential risk of stent separation of sirolimus eluting stent: Accelerated durability tests under in-vivo simulated cyclically-bended proximal right coronary artery environment

American Heart Association Scientific Sessions 20112011/11/16

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Oral presentation(general)

A novel in-vitro immune-response screening system?: Assessment of human blood response to decellularized, freeze-dried, and sterilized xenogeneic tissues

Tissue Engineering and Regenerative Medicine International Society 2011 Asia-Pacific Chapter Meeting2011/08

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Development of in vitro test system to assess hyperacute immune response to decellularized bovine pericardium using human donor blood

Tissue Engineering and Regenerative Medicine International Society 2010 North America Annual Meeting2010/12

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Oral presentation(general)

Two stenting at coronary artery bifurcation yields show-flow region at carina :In vitro pulsatile flow investigation using elastic 3-dimensional stenotic bifurcated artery replica

American Heart Association Scientific Session 20102010/11

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Oral presentation(general)

Fracture Potentials of Five Drug-Eluting-Stent Platforms in Proximal Right Coronary Artery Replica Under in-vivo Simulated Cyclically-Bended Environment

ACC.102010/03

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Oral presentation(general)

Construction of elastic bifurcation model with stenosis for stent performance test

CCT20102010/01

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Oral presentation(general)

Repeated 3-times-balloon-inflation for stent deployment increases luminal patency of cobalt alloy stent: in vitro investigation using 75% stenotic mechanically-equivalent coronary artery replica

American heart association 2009/11

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Poster presentation

Recent Advance of Biomechanical Technology for Artificial Organs and Tissue Engineering

Department of Orthopedics and Rehabilitation2009/11

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Oral presentation(general)

Decellularized bovine ligaments using microwave irradiation and pulsatile detergent-circulation

22th European Society for Biomaterials2009/09

Detail

Poster presentation

Biomechanical Investigation on optimal sterilization of decellularized pericardium

TERMIS 2nd World Congress2009/08

Detail

Poster presentation

Decellularized porcine aortic heart valve: Regeneration and calcification-prevention in one-year implantation in porcine descending aorta

TERMIS 2nd World Congress2009/08

Detail

Oral presentation(general)

Flow Study at Bifurcation

2009/05

Detail

Oral presentation(general)

Successful reproduction on in-vivo fracture of an endovascular stent in superficial femoral artery utilizing a novel multi- loading durability test system

13th International Conference on Biomedical Engineering, pp.131-1322008/12

Detail

Oral presentation(general)

Successful reproduction on in-vivo fracture of an endovascular stent in superficial femoral artery utilizing a novel multi-loading durability test system

13th International Conference on Biomedical Engineering2008/12

Detail

Oral presentation(general)

Tissue engineered small-diametaer blood vessel for coronary artery bypass grafting

The TERMIS North America 2008 Annual Conference & Exposition2008/12

Detail

Poster presentation

Tissue engineering artery utilizing the physiologic pulsatile bioreactor

European Society for Artificial Organs2008/07

Detail

Oral presentation(general)

A novel multi-loading accelerated durability test system for peripheral vascular stents

European Society for Artificial Organs2008/07

Detail

Poster presentation

The novel decellularized bovine medial collateral ligaments for regenerative medicine,6th International Conference of The International Society for Gerontechnology

6th International Conference of The International Society for Gerontechnology2008/06

Detail

Oral presentation(general)

人工臓器開発の経験を駆使した再生医療基盤技術の開発

2008/03

Detail

Oral presentation(general)

A Robust Artery Engineered Using the Novel Pulsatile Pressure and Flow Bioreactor Sustem Controllable of Favorable Gas Concentration

TERMIS-AP 20072007/12

Detail

Oral presentation(general)

In vitro quantitative assessment of thrombogenicity of a pulsatile ventricular assist device using the original circulation system

2007 JSAO-IFAO Joint Congress2007/10

Detail

Oral presentation(general)

In vitro quantitative assessment of thrombogenicity of a pulsatile ventricular assist device using the original circulation system

2007/10

Detail

Oral presentation(general)

Tissue Engineered Three-layered Artery Using Hemodynamically-equivalent Pulsatile Bioreactor

Scientific Sessions 20072007/10

Detail

Oral presentation(general)

Innovative bioreactor technologies produced a completely decellularized and pre-endothelialized functional aortic valve

The 12th International Conference on Biomedical Engineering2005/12

Detail

Oral presentation(general)

Microwave treatment combined with pulsatile circulation can completely remove cells and α1-3 galactose antigen; vortex pump

ESAO2005 congress IFAO20052005/10

Microwave treatment combined with pulsatile circulation can completely remove cells and α1-3 galactose antigen

2005 ESAO-IFAO Joint Congress2005/09

Detail

Oral presentation(general)

In vitro anti-thrombogenic screening of biomaterials under practical pulsatile circulation

2005 ESAO-IFAO Joint Congress2005/09

Detail

Oral presentation(general)

A completely decellularized and pre-cellularized tissue engineered aortic valve using innovative bioreactor technologies,Advances in tissue engineering and biology of heart valves

Advances in Tissue Engineering and Biology of Heart Valves2004/09

Detail

Oral presentation(general)

Innovative decellularization and pre-endothelialization technologies to develop a tissue-engineered aortic valve

76th ICB seminar 7th Polish-Japanese Seminar on "New technologies for future artificial organs"2004/09

Detail

Oral presentation(general)

A novel methodology for pre-screening anti-thrombogenicity of artificial organs under physiologically identical pulsatile environments

31th ESAO congress2004/07

Detail

Oral presentation(general)

Development of a completely decellularized and precellularized functional porcine aortic valve

31th ESAO congress2004/07

Detail

Oral presentation(general)

Innovative dynamic bioreactor technologies to realize a pre-endothelialized decellularized aortic heart valve

Regenerate 2004: Tissue Engineering the Human Body2004/06

Detail

Poster presentation

In vitro accelerated calcification tester for biomaterials using real blood

American Society For Artificial Internal Organs2004/06

Detail

Oral presentation(general)

A novel in vitro device to investigate a calcification mechanisum on cardiovascular implants

Workshop on “Advances in Biotechnology and Bioengineering”2004/01

Detail

Oral presentation(general)

Complete decellularization of xenogeneic aortic heart valves and in vitro re-endothelialization in a pulsatile circulation using novel bioreactors

6th Annual International Conference of Tissue Engineering Society International2003/12

Detail

Oral presentation(general)

A novel in vitro methodology for blood compatibility tests for artificial organs in pulsatile flow and pressure environments

World Congress on Medical Physics and Biomedical Engineering2003/08

Detail

Oral presentation(general)

A novel methodology to investigate a calcification potential of polymeric cardiovascular biomaterials under accelerated condition

30th ESAO congress2003/07

Detail

Oral presentation(general)

An inexpensive pulsatile blood pump:Fabrication strategies and in vitro reliable methodology to evaluate blood compatibility

International Congress on Biolagcal and Medical Engineering The Bio-Era:New Frontiers2002/12

Detail

Oral presentation(general)

Development of a novel in-vitro closed circuit for anti-thrombogenic tests of cardiac prostheses under physiologic hemodynamic conditions

48th conference ASAIO2002/06

Detail

Oral presentation(general)

Importance of dynamic-load conditions in the accelerated fatigue tests for polymer heart valves

13th World Congress of international Society for Artificial Organs2001/10

Detail

Oral presentation(general)

The improved jellyfish valve: Durability enhancement with Sufficient blood compatibility

47th Annual conference on ASAIO2001/04

Detail

Oral presentation(general)

Analysis of calification mechanism on jellyfish valve

2nd Japan Australia CARDIOVASCULAR2000/03

Detail

Oral presentation(general)

Extension of a duraaaability of jellyfish valve for long-term use in artificial hearts

Artificial Heart and Assist Devices2000/03

Detail

Oral presentation(general)

Analysis of calification mechanism on jellyfish valve

Japan Australia CARDIOVASCULAR2000/03

Detail

Oral presentation(general)

Development of a durable of a durable polymer valve based on finite element analysis

APCMB'991999/09

Detail

Oral presentation(general)

In vitro performance of coronary stents

The 3rd world congress of biomechanics1998/08

Detail

Oral presentation(general)

Tissue-engineered robust vascular grafts utilizing the physiologically equivalent pulsatile bioreactor

8th World Biomaterials Congress

Detail

Poster presentation

無細胞化腱を用いた異種動物の前十字靭帯再建による再性能評価

岩﨑清隆

2016/06/06

Detail

Oral presentation(general)

冠動脈分岐部でのステント不完全圧着と血流~先進的な非臨床試験からの洞察~

岩﨑清隆

2015/07/31

Detail

Oral presentation(general)

左心補助人工心臓の耐久試験法:日本初補助人工心臓の非臨床評価において留意した点,医用アクチュエーション研究会講演会「医用アクチュエーションの最近の話題」

岩﨑清隆

2015/09/15

Detail

Oral presentation(general)

先進的人工弁・弁膜治療法の実用化と安全な普及を加速する非臨床評価試験法の開発

岩﨑清隆

2015/11/21

Detail

Oral presentation(general)

滅菌済無細胞化ウシ腱を用いたラット膝前十字靭帯再建による再生能と炎症反応評価

岩﨑清隆

2015/11/21

Detail

Oral presentation(general)

滅菌済無細胞化ウシ腱を用いたラット膝前十字靭帯再建による再生能と炎症反応評価

岩﨑清隆

2015/11/21

Detail

Oral presentation(general)

革新的医療機器実現化のためのEngineering Based Medicineに基づく非臨床性能評価系と評価法の開発

岩﨑清隆

2016/01/09

Detail

Oral presentation(general)

Patent

Reference Number:880

保存処理時の生体組織の保持方法及び保持具、並びに保存処理された生体組織(日本)

岩崎 清隆, 梅津 光生

2009-152658、2011- 5043、5424147

Reference Number:939

模擬狭窄血管及びその製造方法(日本)

岩崎 清隆, 梅津 光生, 坪内 俊介, 濱 悠太朗, 八木下 雄一

2009- 69196、2010-224069、5136993

Reference Number:1059

移植用人工弁尖及びその製造方法(日本)

梅津 光生, 岩崎 清隆, 尾崎 重之

2010-118015、2011-244862

Reference Number:1061

無細胞化方法及び人体移植用人工組織(日本, PCT)

岩崎 清隆, 太田 友博, 梅津 光生

2010-112606、2013-165740

Reference Number:1101

血液適合性等の評価用の実験方法(日本)

岩崎 清隆, 梅津 光生, 東宮 裕人, 利根川 明宏, 宮川 充

2010-267806、2012-117910、5561130

Reference Number:140-JP

医療機器の耐久試験装置及び耐久試験方法(日本)

岩崎 清隆, 梅津 光生, 錦織 晃, 坪内 俊介

2009-531143、5051234

Reference Number:169-JP

模擬血管製造用のモールド、模擬血管の製造方法、及び模擬血管(日本)

田中 隆, 岩崎 清隆, 梅津 光生

2010-520786、2010- 7801、4974253

Reference Number:284-JP

生体組織の処理方法及び生体組織(日本)

岩崎 清隆, 梅津 光生

2014-508253、6078838

Research Grants & Projects

Grant-in-aids for Scientific Research Adoption Situation

Research Classification:

Developement of a new stentless mitral valve for clinical application

2011-2013

Allocation Class:¥18980000

Research Classification:

Mechanical stimulation-induced vascular elastogenesis

2010-2011

Allocation Class:¥3120000

Research Classification:

The research and development of durable decellularized aortic valves in collaboration with engineers.

Allocation Class:¥17230000

Research Classification:

Flow field analysis of the flow around and inside the valsalva and of the coronary flow influenced by the prosthetic aortic valve

Allocation Class:¥3600000

Research Classification:

Development of evaluation system for artificial organs from the viewpoints of clinical study, engineering, and statistics.

Allocation Class:¥2500000

Research Classification:

Establishment of support technology for the development of surgical training simulator

Allocation Class:¥13700000

Research Classification:

Establishment of a three-dimensional strain measurement method for the quantitative evaluation of transcatheter aortic valve deployment

2018/-0-2021/-0

Allocation Class:¥4420000

Research Classification:

Study on in vivo ligamentization of decellularized tissue in knee anterior cruciate ligament reconstruction using large animal models

2017/-0-2020/-0

Allocation Class:¥17810000

Research Classification:

Development of a pulsatile simulator fir quantitatively assess procedural outcomes of stent grafts for thoracic artery aneurysm

2015/-0-2017/-0

Allocation Class:¥3640000

Research Classification:

Evaluation of aortic root geometry and aortic valve function following various valve-preserving root replacements

2015/-0-2018/-0

Allocation Class:¥4810000

Research Classification:

Usability-oriented system development of a surgical navigation for aortic vascular surgery

2014/-0-2017/-0

Allocation Class:¥4810000

Research Classification:

Development of visualization method of stent thrmobosis in bifurcated coronary artery

2019/-0-2022/-0

Allocation Class:¥4290000

Research Classification:

Novel classification system for assesing risk of progressive ascending aortic dialation associated with bicuspid aortic valve

2019/-0-2022/-0

Allocation Class:¥4290000

Research Classification:

Assessment of bicuspid aortic valve configuration providing optimal hemodynamics: towards development of aortic valve repair ring

2019/-0-2022/-0

Allocation Class:¥4420000

On-campus Research System

Special Research Project

心臓の収縮・拡張に伴う冠動脈屈曲運動下でのステント破損予測解析

2013

Research Results Outline: 冠動脈ステント治療は,本邦で年間7%程度のステント破断が生じ,破断したステントでの再狭窄率は85%程度と非常に高い報告もある.一度留置すると取り出せ 冠動脈ステント治療は,本邦で年間7%程度のステント破断が生じ,破断したステントでの再狭窄率は85%程度と非常に高い報告もある.一度留置すると取り出せないため,冠動脈に留置されるステントには高い破損耐久性が求められる.我々は心臓の収縮・拡張に伴う右... 冠動脈ステント治療は,本邦で年間7%程度のステント破断が生じ,破断したステントでの再狭窄率は85%程度と非常に高い報告もある.一度留置すると取り出せないため,冠動脈に留置されるステントには高い破損耐久性が求められる.我々は心臓の収縮・拡張に伴う右冠動脈の屈曲変形に着目し,実臨床に即した冠動脈ステントの屈曲加速耐久試験装置を開発した.患者から得た右冠動脈屈曲角度の平均値である収縮期105deg,拡張期125degの角度を屈曲冠動脈モデルに作用する加速耐久試験装置を開発し,デザイン・材質の異なるステントに対し,屈曲加速耐久試験を実施してきた.本研究では,耐久試験結果でのステント破断の原因を明確化し,ステント破断予測を行うシステムを構築するため,有限要素法を用いた冠動脈屈曲変形下におけるステントの応力解析方法の構築を目的とした.解析はステント製造から実臨床で使用される一連の手順を踏まえ,以下の3ステップに分けた.(1)ステントをバルーンにかしめる圧縮解析(2)血管モデル内で円筒状にモデル化したバルーンを用いたステントの拡張・留置解析(3)ステントに屈曲負荷を作用させる屈曲負荷解析(3)の屈曲負荷解析は,血管モデルに収縮期105deg,拡張期125degを屈曲角度とする屈曲変形を作用させ,ステントへ間接的に屈曲負荷を作用させた.臨床で使用されているCoCr製のステントを対象とし,解析には非線形有限要素解析ソフト(ADINA8.9,ニュートンワークス)を使用した.解析より得たMisesの相当応力から応力振幅と平均応力を求め,疲労安全率を算出した.疲労安全率は屈曲中央のリンク部およびリンクが接合しているクラウン部で小さいことが明らかとなった.本解析対象ステントは耐久試験において,屈曲中央のリンク部でステント破断が生じており,疲労安全率の小さい部位と一致する傾向を確認できた.以上より,ステントをバルーンにかしめ,バルーンでステントを血管内に拡張し,屈曲変形を作用させる一連の有限要素解析方法を構築した.

脳血管血栓回収ステントの有効性向上の設計指針を取得する先進的生体代替試験法の開発

2017Collaborator:松橋祐輝

Research Results Outline:心臓で血流停滞により形成された血栓により脳血管が閉塞すると、死亡や重度の障害を招く。そこで発症から8時間以内の急性期脳梗塞患者に対して、NiTi合金製心臓で血流停滞により形成された血栓により脳血管が閉塞すると、死亡や重度の障害を招く。そこで発症から8時間以内の急性期脳梗塞患者に対して、NiTi合金製の網目状構造を有する血栓回収デバイスで血栓を絡め、血管内で引き抜いてカテーテル内に収納して回収し、...心臓で血流停滞により形成された血栓により脳血管が閉塞すると、死亡や重度の障害を招く。そこで発症から8時間以内の急性期脳梗塞患者に対して、NiTi合金製の網目状構造を有する血栓回収デバイスで血栓を絡め、血管内で引き抜いてカテーテル内に収納して回収し、血流の再開通を図る治療法がある。本研究では、血栓回収デバイスの安全で有効な使用方法を開発することを目指し、血液を用いて血栓を作製し、その力学的特性を調整する方法、また、血栓の圧縮剛性等を計測する評価系を開発した。さらに、デバイス展開後にどのくらい待つと血栓が押し広げられて拡張径が一定値に漸近するのかを検証し、実臨床に貢献する知見を得ることができた。

大動脈ステントグラフトを用いた治療目標達成度を評価する拍動流シミュレータ開発

2015Collaborator:植松美幸, 山崎健二

Research Results Outline:弓部大動脈瘤の治療は、治療効果の高いステントグラフトの開発が望まれ、手技の難易度の高い挑戦的領域である。その理由は、心臓から拍動血流による負荷を受ける弓部大動脈瘤の治療は、治療効果の高いステントグラフトの開発が望まれ、手技の難易度の高い挑戦的領域である。その理由は、心臓から拍動血流による負荷を受ける中でステントグラフトを展開し、ステントグラフトを曲がってねじれた血管壁に圧着させて瘤への血流を遮断...弓部大動脈瘤の治療は、治療効果の高いステントグラフトの開発が望まれ、手技の難易度の高い挑戦的領域である。その理由は、心臓から拍動血流による負荷を受ける中でステントグラフトを展開し、ステントグラフトを曲がってねじれた血管壁に圧着させて瘤への血流を遮断しつつ、脳を還流する三分枝血管への血流を阻害しないことが要求されるためである。新規デバイスを患者に使う前に拍動流環境で操作性を体感でき、留置結果を定量評価できると、治療戦略立案に役立ち、治療手技の向上にも貢献し得る。本研究では、ステントグラフトの挿入から留置を弾性血管モデル内で拍動流存在下に体験し、留置結果を定量評価できるシミュレータを開発した。

Lecture Course

Course TitleSchoolYearTerm
Basic Experiments in Science and Engineering 2A SougoukikaiSchool of Creative Science and Engineering2019spring semester
Engineering MechanicsSchool of Creative Science and Engineering2019spring semester
Engineering Mechanics [S Grade]School of Creative Science and Engineering2019spring semester
Materials EngineeringSchool of Creative Science and Engineering2019fall semester
Materials Engineering [S Grade]School of Creative Science and Engineering2019fall semester
Fluid Dynamics FSchool of Creative Science and Engineering2019fall semester
Fluid Dynamics F [S Grade]School of Creative Science and Engineering2019fall semester
Mechanical Engineering Laboratory Fund.School of Creative Science and Engineering2019spring semester
Mechanical Engineering Laboratory Fund. [S Grade]School of Creative Science and Engineering2019spring semester
Mechanical Engineering Laboratory Adv.School of Creative Science and Engineering2019fall semester
Mechanical Engineering Laboratory Adv. [S Grade]School of Creative Science and Engineering2019fall semester
SeminarSchool of Creative Science and Engineering2019full year
Seminar [S Grade]School of Creative Science and Engineering2019full year
Engineering PracticeSchool of Creative Science and Engineering2019full year
Engineering Practice [S Grade]School of Creative Science and Engineering2019full year
Graduation ThesisSchool of Creative Science and Engineering2019full year
Graduation Thesis [S Grade]School of Creative Science and Engineering2019full year
BioengineeringSchool of Creative Science and Engineering2019fall semester
Graduation Thesis ASchool of Creative Science and Engineering2019fall semester
Graduation Thesis A [S Grade]School of Creative Science and Engineering2019fall semester
Graduation Thesis BSchool of Creative Science and Engineering2019spring semester
Graduation Thesis B [S Grade]School of Creative Science and Engineering2019spring semester
Seminar ASchool of Creative Science and Engineering2019spring semester
Engineering Practice ASchool of Creative Science and Engineering2019spring semester
Seminar BSchool of Creative Science and Engineering2019fall semester
Engineering Practice BSchool of Creative Science and Engineering2019fall semester
Mechanical Engineering Laboratory ASchool of Creative Science and Engineering2019spring semester
Mechanical Engineering Laboratory BSchool of Creative Science and Engineering2019fall semester
Seminar CSchool of Creative Science and Engineering2019spring semester
Engineering Practice CSchool of Creative Science and Engineering2019spring semester
Master's Thesis (Department of Modern Mechanical Engineering)Graduate School of Creative Science and Engineering2019full year
Internal Organ EngineeringGraduate School of Creative Science and Engineering2019fall semester
Internal Organ EngineeringGraduate School of Advanced Science and Engineering2019fall semester
Internal Organ EngineeringGraduate School of Advanced Science and Engineering2019fall semester
Materials EngineeringGraduate School of Creative Science and Engineering2019fall semester
Master's Thesis (Department of Modern Mechanical Engineering)Graduate School of Creative Science and Engineering2019full year
Master's Thesis (Department of Integrative Bioscience and Biomedical Engineering)Graduate School of Advanced Science and Engineering2019full year
Research on Medical Mechanical Engineering and its ApplicationGraduate School of Creative Science and Engineering2019full year
Research on Medical Mechanical Engineering and its ApplicationGraduate School of Creative Science and Engineering2019full year
Research on Medical Mechanical Engineering and its ApplicationGraduate School of Advanced Science and Engineering2019full year
Research on Medical Mechanical Engineering and its ApplicationGraduate School of Advanced Science and Engineering2019full year
Integrative Bioscience and Biomedical Engineering AGraduate School of Advanced Science and Engineering2019spring semester
Integrative Bioscience and Biomedical Engineering AGraduate School of Advanced Science and Engineering2019spring semester
Integrative Bioscience and Biomedical Engineering AGraduate School of Advanced Science and Engineering2019spring semester
Integrative Bioscience and Biomedical Engineering BGraduate School of Advanced Science and Engineering2019fall semester
Integrative Bioscience and Biomedical Engineering BGraduate School of Advanced Science and Engineering2019fall semester
Practical Medical EngineeringGraduate School of Creative Science and Engineering2019spring semester
Practical Medical EngineeringGraduate School of Advanced Science and Engineering2019spring semester
Practical Medical EngineeringGraduate School of Advanced Science and Engineering2019spring semester
Practical Medical EngineeringGraduate School of Advanced Science and Engineering2019spring semester
Seminar on Medical Mechanical Engineering AGraduate School of Creative Science and Engineering2019spring semester
Seminar on Medical Mechanical Engineering AGraduate School of Creative Science and Engineering2019spring semester
Seminar on Medical Mechanical Engineering AGraduate School of Advanced Science and Engineering2019spring semester
Seminar on Medical Mechanical Engineering AGraduate School of Advanced Science and Engineering2019spring semester
Seminar on Medical Mechanical Engineering BGraduate School of Creative Science and Engineering2019fall semester
Seminar on Medical Mechanical Engineering BGraduate School of Creative Science and Engineering2019fall semester
Seminar on Medical Mechanical Engineering BGraduate School of Advanced Science and Engineering2019fall semester
Seminar on Medical Mechanical Engineering BGraduate School of Advanced Science and Engineering2019fall semester
Seminar on Medical Mechanical Engineering CGraduate School of Creative Science and Engineering2019spring semester
Seminar on Medical Mechanical Engineering CGraduate School of Creative Science and Engineering2019spring semester
Seminar on Medical Mechanical Engineering CGraduate School of Advanced Science and Engineering2019spring semester
Seminar on Medical Mechanical Engineering CGraduate School of Advanced Science and Engineering2019spring semester
Seminar on Medical Mechanical Engineering DGraduate School of Creative Science and Engineering2019fall semester
Seminar on Medical Mechanical Engineering DGraduate School of Creative Science and Engineering2019fall semester
Seminar on Medical Mechanical Engineering DGraduate School of Advanced Science and Engineering2019fall semester
Seminar on Medical Mechanical Engineering DGraduate School of Advanced Science and Engineering2019fall semester
Master's Thesis (Department of Integrative Bioscience and Biomedical Engineering)Graduate School of Advanced Science and Engineering2019full year
Research on Medical Applications of Mechanical EngineeringGraduate School of Creative Science and Engineering2019full year
Research on Medical Applications of Mechanical EngineeringGraduate School of Advanced Science and Engineering2019full year
Research on Clinical Application, Development and Evaluation of the Instruments with Advanced Medical TherapyGraduate School of Advanced Science and Engineering2019full year
Research on Cardiovascular Biomedical EngineeringGraduate School of Advanced Science and Engineering2019full year
Clinical StudiesGraduate School of Advanced Science and Engineering2019spring quarter
Medical regulatory scienceGraduate School of Advanced Science and Engineering2019spring quarter
Introduction to GLP/GCP/GMPGraduate School of Advanced Science and Engineering2019an intensive course(spring)
Seminar on Advanced MedicineGraduate School of Advanced Science and Engineering2019fall quarter
Seminar on Clinical StudiesGraduate School of Advanced Science and Engineering2019winter quarter
Seminar on Medical regulatory scienceGraduate School of Advanced Science and Engineering2019winter quarter
Seminar on Medical RS BGraduate School of Advanced Science and Engineering2019an intensive course(fall)
Seminar on Medical RS AGraduate School of Advanced Science and Engineering2019spring semester
Seminar on Medical RS DGraduate School of Advanced Science and Engineering2019fall semester
Seminar on Medical RS CGraduate School of Advanced Science and Engineering2019an intensive course(fall)