Takamizawa, Naoko; Shioya, Nobuhiko; Nagaoka, Hiromasa; Uchino, Takayuki
Japanese Pharmacology and Therapeutics44(2)p.207 - 2172016年01月-2016年01月
概要：Objectives: The aim of this study was to evaluate the effect and safety of a dietary supplement (Kojun premium®) containing hyaluronic acid derived from chicken combs on knee pain, stiffness and discomfort. Methods: We conducted a randomized, double-blind, placebo-controlled, parallel-group comparison study. The subjects, 80 adults whose Kellgren-Lawrence classification of osteoarthritis of the knee corresponded to 0-II and who were not suffering from the disease, were randomly divided into two groups: the test product (chicken comb extract-containing supplement) group and the control product (placebo) group. Knee pain and discomfort were evaluated using a visual analogue scale (VAS). The subjects were given each product for 12 weeks. Blood and urine samples were tested to evaluate the safety of the test product. Results: Significant positive results demonstrating the effectiveness of the chicken comb extract-containing supplement appeared 4-12 weeks after the intake as demonstrated by the VAS scores. The blood test results did not indicate any health hazard from the use of these supplements. Conclusion: These results indicate that an intake of hyaluronic acid-containing supplements derived from chicken combs is safe and effective in managing knee pain, stiffness and discomfort.
Moto, Mihoko; Moto, Mihoko; Takamizawa, Naoko; Shibuya, Tetsuhei; Nakamura, Asae; Katsuraya, Kaname; Iwasaki, Kazuyasu; Tanaka, Katsuyuki; Murota, Akihiko
Journal of Functional Foods40p.336 - 3402018年01月-2018年01月
概要：© 2017 We evaluated the inhibitory effects of CS with different molecular weights from 170,000 to 10,000 Da on a-glucosidase activity in vitro. Low-molecular-weight CS ( < 16,000 Da) showed a higher inhibition of a-glucosidase activity than high-molecular-weight CS. In addition, we examined the effects of a single administration of low-molecular-weight CS on postprandial blood glucose in ICR mice. Low-molecular-weight CS inhibited the elevation of postprandial blood glucose in mice loaded with sucrose or starch as the source of carbohydrates. Finally, we investigated the anti-diabetic effects of daily administration of low- molecular-weight CS using type 2 diabetes model KK-Ay mice. The elevation of fasting blood glucose was inhibited in the CS group. These results suggest that the administration of low-molecular-weight CS prevents the elevation in the postprandial blood glucose level by reducing the digestion of carbohydrates in the gastrointestinal tract, leading to reductions of hyperglycemia in KK-Ay mice.
竹山 春子, 矢澤 一良, 高見澤 菜穂子, 青木 菜摘