氏名

イケ ユウキ

池 勇樹

職名

助手

所属

(先進理工学部)

学歴・学位

学位

修士

学内研究制度

特定課題研究

超音波誘導核化手法を用いたアミノ酸結晶の多形制御とその機構の解明

2018年度

研究成果概要:Amino acids have been used in medical field and food field. However, design condition of production process of the ...Amino acids have been used in medical field and food field. However, design condition of production process of the amino acid crystal is limited because most of the amino acids show polymorphism. In this study, polymorph control of L-Arginine hydrochloride and L-phenylalanine by ultrasonic irradiation was confirmed, and the mechanism of selective crystallization was discussed in terms of local supersaturation at cavitation bubble. The cavitation bubble was observed by high speed camera and digital camera, and the concentration of bubbles was quantified by the camera images. The results suggest that higher output of ultrasonic irradiation would cause higher bubble concentration. In addition, experiment of crystallization using micro bubble generator was performed and the primary nucleation rate of each polymorph under the existence of micro bubble was observed. Subsequently, the ultrasonic-induced nucleation and the bubble-induced nucleation were analyzed using classical nucleation theory. The results suggested that the generation of bubbles would be one of the causes of polymorph control by ultrasonic-induced nucleation. These results were reported at international conference (Asian Crystallization Technology Symposium 2018).

超音波誘導核化手法を用いたアミノ酸の多形制御とその機構の速度論的検討

2019年度

研究成果概要:Amino acids have been used in medical field and food field. However, design condition of production process of the ...Amino acids have been used in medical field and food field. However, design condition of production process of the amino acid crystal is limited because most of the amino acids show polymorphism. In this study, polymorph control of L-Arginine hydrochloride and L-phenylalanine by ultrasonic irradiation was confirmed, and the mechanism of selective crystallization was discussed based on classical nucleation theory. The cavitation bubble, which was formed by ultrasonic vibration, was observed by high speed camera and digital camera. In addition, the concentration of bubbles was quantified by the camera images. The results suggest that higher output of ultrasonic irradiation would cause higher bubble concentration. Moreover, experiment of mL-scale crystallization was performed, and primary nucleation rate of each polymorph was observed to discuss the nucleation probability. The results indicate that the ultrasonication would induce the nucleation of particular form significantly, and nucleation probability was increased for several hours after the irradiation. Therefore, the surfaces of bubbles generated by ultrasonic vibration would be one of mechanisms of ultrasonic-induced nucleation. These results were reported at international conferences (BIWIC 2019 and APCChE 2019).